卵泡在线：一个关于卵泡组装、发育和排卵的综合数据库。
Follicle Online: an integrated database of follicle assembly, development and ovulation.
作者信息
Hua Juan, Xu Bo, Yang Yifan, Ban Rongjun, Iqbal Furhan, Cooke Howard J, Zhang Yuanwei, Shi Qinghua
机构信息
Molecular and Cell Genetics Laboratory, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China, Center for Reproductive Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China, Department of Statistics, University of Kentucky, Lexington, KY 40506, USA, Collaborative Innovation Center of Genetics and Development, Fudan University, 2005 Songhu Road, Shanghai 200438, China, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China and Institute of Pure and Applied Biology, Bahauddin Zakariya University Multan, 60800, Pakistan Molecular and Cell Genetics Laboratory, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China, Center for Reproductive Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China, Department of Statistics, University of Kentucky, Lexington, KY 40506, USA, Collaborative Innovation Center of Genetics and Development, Fudan University, 2005 Songhu Road, Shanghai 200438, China, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China and Institute of Pure and Applied Biology, Bahauddin Zakariya University Multan, 60800, Pakistan.
Molecular and Cell Genetics Laboratory, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China, Center for Reproductive Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China, Department of Statistics, University of Kentucky, Lexington, KY 40506, USA, Collaborative Innovation Center of Genetics and Development, Fudan University, 2005 Songhu Road, Shanghai 200438, China, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China and Institute of Pure and Applied Biology, Bahauddin Zakariya University Multan, 60800, Pakistan.
出版信息
Database (Oxford). 2015 Apr 29;2015:bav036. doi: 10.1093/database/bav036. Print 2015.
Folliculogenesis is an important part of ovarian function as it provides the oocytes for female reproductive life. Characterizing genes/proteins involved in folliculogenesis is fundamental for understanding the mechanisms associated with this biological function and to cure the diseases associated with folliculogenesis. A large number of genes/proteins associated with folliculogenesis have been identified from different species. However, no dedicated public resource is currently available for folliculogenesis-related genes/proteins that are validated by experiments. Here, we are reporting a database 'Follicle Online' that provides the experimentally validated gene/protein map of the folliculogenesis in a number of species. Follicle Online is a web-based database system for storing and retrieving folliculogenesis-related experimental data. It provides detailed information for 580 genes/proteins (from 23 model organisms, including Homo sapiens, Mus musculus, Rattus norvegicus, Mesocricetus auratus, Bos Taurus, Drosophila and Xenopus laevis) that have been reported to be involved in folliculogenesis, POF (premature ovarian failure) and PCOS (polycystic ovary syndrome). The literature was manually curated from more than 43,000 published articles (till 1 March 2014). The Follicle Online database is implemented in PHP + MySQL + JavaScript and this user-friendly web application provides access to the stored data. In summary, we have developed a centralized database that provides users with comprehensive information about genes/proteins involved in folliculogenesis. This database can be accessed freely and all the stored data can be viewed without any registration. Database URL: http://mcg.ustc.edu.cn/sdap1/follicle/index.php
卵泡发生是卵巢功能的重要组成部分，因为它为女性生殖生命提供卵母细胞。表征参与卵泡发生的基因/蛋白质是理解与这种生物学功能相关的机制以及治疗与卵泡发生相关疾病的基础。已经从不同物种中鉴定出大量与卵泡发生相关的基因/蛋白质。然而，目前没有专门的公共资源可用于经实验验证的卵泡发生相关基因/蛋白质。在这里，我们报告了一个数据库“卵泡在线”，它提供了多个物种中经实验验证的卵泡发生基因/蛋白质图谱。卵泡在线是一个基于网络的数据库系统，用于存储和检索卵泡发生相关的实验数据。它为580个基因/蛋白质（来自23种模式生物，包括智人、小家鼠、褐家鼠、金黄地鼠、牛、果蝇和非洲爪蟾）提供详细信息，这些基因/蛋白质据报道参与卵泡发生、卵巢早衰（POF）和多囊卵巢综合征（PCOS）。文献是从超过43,000篇已发表文章（截至2014年3月1日）中手动筛选的。卵泡在线数据库采用PHP + MySQL + JavaScript实现，这个用户友好的网络应用程序提供对存储数据的访问。总之，我们开发了一个集中式数据库，为用户提供有关参与卵泡发生的基因/蛋白质的全面信息。该数据库可免费访问，所有存储的数据无需任何注册即可查看。数据库网址：http://mcg.ustc.edu.cn/sdap1/follicle/index.php
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