p53基因第72位密码子精氨酸/脯氨酸多态性与基底细胞癌风险：一项荟萃分析
p53 Arg72Pro polymorphism and risk of basal cell carcinoma: a meta analysis.
作者信息
Tian Yanli, Li Li, Yang Rongya
机构信息
Medical School of Chinese PLA, The Chinese PLA General Hospital Beijing, China ; Department of Dermatology, The General Hospital of Beijing Military Command Beijing, China.
Department of Dermatology, The General Hospital of Beijing Military Command Beijing, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2350-6. eCollection 2015.
PURPOSE
We attempted to comprehensively assess the possible association between p53 Arg72Pro polymorphism and the risk of basal cell carcinoma (BCC).
METHODS
We performed a literature search of case-control association studies on p53 Arg72Pro polymorphism and BCC susceptibility in PubMed and EMBASE. 7 eligible studies were finally identified and their data were extracted for this meta-analysis. BCC risk was determined with the fixed effects model using a pooled odds ratio (OR).
RESULTS
Using distinct genetic models, we found that p53 Arg72Pro polymorphism was not associated with the overall risk of BCC. We observed a similar trend towards the association when performing subgroup analysis for Caucasians and Asians.
CONCLUSION
Our results suggest that presence of the common p53 Arg72Pro polymorphism may not play a role in the development of BCC. Larger studies are needed to better confirm the association.
目的
我们试图全面评估p53基因72密码子精氨酸（Arg）突变为脯氨酸（Pro）的多态性与基底细胞癌（BCC）风险之间的可能关联。
方法
我们在PubMed和EMBASE数据库中检索了关于p53基因Arg72Pro多态性与BCC易感性的病例对照关联研究。最终确定了7项符合条件的研究，并提取了它们的数据用于本次荟萃分析。使用固定效应模型和合并比值比（OR）来确定BCC风险。
结果
采用不同的遗传模型，我们发现p53基因Arg72Pro多态性与BCC的总体风险无关。在对高加索人和亚洲人进行亚组分析时，我们观察到了类似的关联趋势。
结论
我们的结果表明，常见的p53基因Arg72Pro多态性可能在BCC的发生中不起作用。需要更大规模的研究来更好地证实这种关联。
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