p53 Arg72Pro 多态性与胃癌的关联：荟萃分析。
Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis.
机构信息
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
出版信息
Biomarkers. 2012 Nov;17(7):597-603. doi: 10.3109/1354750X.2012.704646. Epub 2012 Jul 10.
BACKGROUND
p53 tumor suppressor gene Arg72Pro polymorphism has been associated with gastric cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and gastric cancer.
METHODS
An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assess by pooled odds ratio (ORs) with 95% confidence interval (CIs).
RESULTS
The meta-analysis suggested that the p53 Arg72Pro was associated with the gastric cancer risk (Additive model: OR = 1.149, 95% CI = 1.045-1.263, p = 0.004; Dominant model: OR = 1.18, 95% CI = 1.049-1.328, p = 0.006; Recessive model: OR = 1.202, 95% CI = 1.013-1.427, p = 0.035) in Asian subgroup.
CONCLUSION
This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of gastric cancer in Asians.
背景
p53 肿瘤抑制基因 Arg72Pro 多态性与胃癌有关。然而，结果并不一致。我们进行了这项荟萃分析，以评估 p53 Arg72Pro 多态性与胃癌之间的关系。
方法
通过电子搜索 PubMed 选择研究。选择包含 Arg72Pro 基因型频率的研究，并通过合并优势比（ORs）及其 95%置信区间（CIs）评估相关性。
结果
荟萃分析表明，p53 Arg72Pro 与胃癌风险相关（加性模型：OR=1.149，95%CI=1.045-1.263，p=0.004；显性模型：OR=1.18，95%CI=1.049-1.328，p=0.006；隐性模型：OR=1.202，95%CI=1.013-1.427，p=0.035）在亚洲亚组中。
结论
这项荟萃分析表明，p53 Arg72Pro 多态性与亚洲人群胃癌风险增加相关。
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