中国广西BRCA1基因突变相关乳腺癌的超声特征及乳腺影像报告和数据系统（BI-RADS-US）分类
Ultrasonographic characteristics and BI-RADS-US classification of BRCA1 mutation-associated breast cancer in Guangxi, China.
作者信息
Li Cheng, Liu Junjie, Wang Sida, Chen Yuanyuan, Yuan Zhigang, Zeng Jian, Li Zhixian
机构信息
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2411-6. eCollection 2015.
OBJECTIVE
To retrospectively analyze and compare the ultrasonographic characteristics and BI-RADS-US classification between patients with BRCA1 mutation-associated breast cancer and those without BRCA1 gene mutation in Guangxi, China.
METHODS
The study was performed in 36 lesions from 34 BRCA1 mutation-associated breast cancer patients. A total of 422 lesions from 422 breast cancer patients without BRCA1 mutations served as control group. The comparison of the ultrasonographic features and BI-RADS-US classification between two the groups were reviewed.
RESULTS
More complex inner echo was disclosed in BRCA1 mutation-associated breast cancer patients (x(2) = 4.741, P = 0.029). The BI-RADS classification of BRCA1 mutation-associated breast cancer was lower (U = 6094.0, P = 0.022).
CONCLUSIONS
BRCA1 mutation-associated breast cancer frequently displays as microlobulated margin and complex echo. It also shows more benign characteristics in morphology, and the BI-RADS classification is prone to be underestimated.
目的
回顾性分析并比较中国广西地区携带BRCA1基因突变的乳腺癌患者与未携带BRCA1基因突变的乳腺癌患者的超声特征及美国放射学会（ACR）乳腺影像报告和数据系统（BI-RADS）超声分类。
方法
对34例携带BRCA1基因突变的乳腺癌患者的36个病灶进行研究。选取422例未携带BRCA1基因突变的乳腺癌患者的422个病灶作为对照组。回顾性分析两组患者的超声特征及BI-RADS超声分类并进行比较。
结果
携带BRCA1基因突变的乳腺癌患者内部回声更复杂（χ² = 4.741，P = 0.029）。携带BRCA1基因突变的乳腺癌患者的BI-RADS分类更低（U = 6094.0，P = 0.022）。
结论
携带BRCA1基因突变的乳腺癌常表现为边缘微叶状及回声复杂。其在形态学上也表现出更多良性特征，且BI-RADS分类容易被低估。
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