Maeda K, Katada H, Mikasa K, Konishi M, Shimoyama T, Fukuoka K, Tsujimoto M, Sawaki M, Narita N
2nd Dept. of Int. Med., Nara Medical Univ.
Gan No Rinsho. 1989 Nov;35(14):1631-5.
Taste recognition thresholds for four basic tastes, sweet, salty, and bitter, have been examined in 36 advanced lung cancer patients to identify the presence or absence of taste abnormalities in such patients. Twenty-six untreated lung cancer patients, or 65.3%, demonstrated an abnormal taste threshold for at least one of the 4 taste, a result varying significantly from suitable controls (p less than 0.05). Among the total 36 lung cancer patients, the number of those showing a threshold abnormality was no different between the smoker and non-smoker groups, though abnormalities were higher in the low serum zinc level group than in the normal serum zinc level group (p less than 0.05). We also observed transient threshold elevations after chemotherapy including Cisplatin. Thus, it is thought that taste abnormalities are more prevalent in advanced lung cancer patients.
为了确定晚期肺癌患者是否存在味觉异常，对36例晚期肺癌患者进行了甜、咸、苦四种基本味觉的识别阈值检测。26例未经治疗的肺癌患者（占65.3%）表现出至少一种味觉的阈值异常，这一结果与合适的对照组有显著差异（p小于0.05）。在总共36例肺癌患者中，吸烟者和非吸烟者中味觉阈值异常的人数没有差异，不过低血清锌水平组的异常率高于正常血清锌水平组（p小于0.05）。我们还观察到包括顺铂在内的化疗后味觉阈值短暂升高。因此，人们认为味觉异常在晚期肺癌患者中更为普遍。
