[白血病细胞匀浆中促凝血及纤维蛋白溶解活性]

[Activity of procoagulant and fibrinolysis in homogenate of leukemic cells].

作者信息

Wada H, Tanigawa M, Suzuki H, Takagi M, Mori Y, Ohno T, Kita K, Kobayashi T, Deguchi K, Shirakawa S

出版信息

Rinsho Ketsueki. 1989 Oct;30(10):1783-7.

Abstract

We examined activities of procoagulant and fibrinolysis in homogenate of leukemic cells. Procoagulant activity (PCA) was increased in patients with acute myelocytic leukemia (AML) and acute promyelocytic leukemia (APL), but it was significantly decreased in patients with chronic myelocytic leukemia (CML) and adult T cell leukemia. In CML, PCA was increased in the blastic phase. Plasminogen activator activity (PLGAA) was also increased in patients with AML, APL and acute lymphocytic leukemia (ALL) associated with disseminated intravascular coagulation (DIC). Elastase-like activity, trypsin-like activity and chymotrypsin-like activity (CTLA) were increased in those with myelocytic leukemia, but they were low in those with lymphocytic leukemia. PCA, PLGAA and CTLA were significantly higher in patients with DIC than in those without DIC. Measurement of procoagulant and fibrinolytic activity in leukemic cells homogenate may be useful not only for studying hemostatic abnormalities but also for classification of leukemic cells.

摘要

我们检测了白血病细胞匀浆中的促凝和纤溶活性。急性髓细胞白血病（AML）和急性早幼粒细胞白血病（APL）患者的促凝活性（PCA）升高，但慢性髓细胞白血病（CML）和成人T细胞白血病患者的PCA显著降低。在CML中，原始细胞期PCA升高。伴有弥散性血管内凝血（DIC）的AML、APL和急性淋巴细胞白血病（ALL）患者的纤溶酶原激活物活性（PLGAA）也升高。髓细胞白血病患者的弹性蛋白酶样活性、胰蛋白酶样活性和糜蛋白酶样活性（CTLA）升高，但淋巴细胞白血病患者的这些活性较低。DIC患者的PCA、PLGAA和CTLA显著高于无DIC患者。检测白血病细胞匀浆中的促凝和纤溶活性不仅有助于研究止血异常，还可用于白血病细胞的分类。