†Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, People's Republic of China.
‡Marine Drugs Research Center, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, People's Republic of China.
J Nat Prod. 2015 May 22;78(5):1169-73. doi: 10.1021/acs.jnatprod.5b00081. Epub 2015 May 1.
Four new macrocyclic lactones, bryostatin 21 (1) and 9-O-methylbryostatins 4, 16, and 17 (2-4), together with three known related compounds, bryostatins 4, 16, and 17 (5-7), have been isolated from an extract of the South China Sea bryozoan Bugula neritina. The structures of all compounds were unambiguously elucidated using detailed spectroscopic analysis. Structurally, the presence of a single methyl group at C-18 in compound 1 has not been observed before for known bryostatins. The isolated macrolides exhibited inhibitory effects against a small panel of human cancer cell lines.
从南海苔藓虫（Bugula neritina）提取物中分离得到了四个新的大环内酯化合物，分别为 bryostatin 21（1）和 9-O-甲基 bryostatins 4、16 和 17（2-4），以及三个已知的相关化合物 bryostatins 4、16 和 17（5-7）。所有化合物的结构均通过详细的光谱分析得到明确阐明。结构上，化合物 1 中 C-18 位存在一个单甲基取代基，这在已知的 bryostatin 中尚未观察到。分离得到的大环内酯化合物对一组小型人癌细胞系表现出抑制作用。
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