认识布加综合征。

Understanding Brugada syndrome.

作者信息

Gehshan Janine Mary, Rizzolo Denise

机构信息

Janine Mary Gehshan practices in the cardiac electrophysiology laboratory at New York University Langone Medical Center and works per diem in the postanesthesia care unit at Memorial Sloan Kettering Cancer Center, both in New York City. She is a recent graduate of the Pace completion program in New York City. Denise Rizzolo is an assistant clinical professor in the Pace completion program, an associate professor in the PA program at Seton Hall University in South Orange, N.J., and practices urgent care in Springfield, N.J. The authors have disclosed no potential conflicts of interest, financial or otherwise.

出版信息

JAAPA. 2015 Jun;28(6):32-6. doi: 10.1097/01.JAA.0000465217.11857.ab.

DOI:10.1097/01.JAA.0000465217.11857.ab

PMID:25932713

Abstract

Brugada syndrome is an established cause of sudden cardiac arrest in patients without structural cardiac abnormalities. Recognition and diagnosis of this syndrome has been slowly increasing. Syncope, ventricular dysrhythmia, or sudden cardiac arrest may be the presenting symptom, although detection of the characteristic right precordial ST-segment elevation on ECG can be a potentially lifesaving intervention. This article reviews the clinical presentation, pathophysiology, genetics, and current management of Brugada syndrome.

摘要

Brugada综合征是无结构性心脏异常患者发生心脏性猝死的既定原因。对该综合征的识别和诊断一直在缓慢增加。晕厥、室性心律失常或心脏性猝死可能是首发症状，尽管在心电图上检测到特征性的右胸前导联ST段抬高可能是一种潜在的挽救生命的干预措施。本文综述了Brugada综合征的临床表现、病理生理学、遗传学及当前的治疗方法。