Kawamura T, Koizumi F, Ishimori A
Nihon Shokakibyo Gakkai Zasshi. 1989 Oct;86(10):2373-8.
Ursodeoxycholic acid (UDCA) has been used in the medical treatment of various gastrointestinal diseases. In this study, UDCA-supplemented rats were investigated to elucidate the role of UDCA in the pathogenesis of gastric mucosal lesions induced by water immersion restraint stress. In UDCA-administered rats, the increase of gastric mucosal lipid peroxide (LOP) and ulcer index after 2 hour's stress were prevented as compared with the rats fed on standard diet to serve as the control. In addition, the increase of serum and gastric mucosal catalase after the stress were also suppressed. These results suggested that antioxidant effect of UDCA on the lipid peroxidation may play a role in prevention of gastric lesions induced by water immersion restraint stress.
熊去氧胆酸（UDCA）已被用于多种胃肠道疾病的医学治疗。在本研究中，对补充了UDCA的大鼠进行了研究，以阐明UDCA在水浸束缚应激诱导的胃黏膜损伤发病机制中的作用。与以标准饮食喂养作为对照的大鼠相比，给予UDCA的大鼠在应激2小时后胃黏膜脂质过氧化物（LOP）和溃疡指数的增加得到了预防。此外，应激后血清和胃黏膜过氧化氢酶的增加也受到了抑制。这些结果表明，UDCA对脂质过氧化的抗氧化作用可能在预防水浸束缚应激诱导的胃损伤中发挥作用。
