Université Lille 1, Unité Matériaux et Transformations (UMET) UMR CNRS 8207, Villeneuve d'Ascq, France.
Université Montpellier 1 and 2, Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247, Montpellier, France.
Carbohydr Polym. 2015 Aug 1;126:156-67. doi: 10.1016/j.carbpol.2015.02.064. Epub 2015 Mar 18.
A polyelectrolyte multilayer film (PEM) based on cationic and anionic β-cyclodextrin polyelectrolytes was coated onto a textile substrate for future drug delivery purposes. We firstly synthesized a novel cationic β-cyclodextrin polymer (polyEPG-CD) by crosslinking β-cyclodextrin (βCD) with epichlorohydrin (EP) under basic conditions, in the presence of glycidyltrimetrylammonium chloride (GTMAC) as cationizing group. The influence of preparation conditions has been investigated in order to preferably obtain a water soluble fraction whose charge density and molecular weights were optimal for the layer-by-layer (LbL) deposition process. The different cationic cyclodextrin polymers obtained were characterized by FTIR, NMR, colloidal titration, conductimetry, thermogravimetric analysis and size exclusion chromatography. Besides, the counterpart polyelectrolyte was a β-cyclodextrin polymer crosslinked with citric acid, polyCTR-CD, whose synthesis and characterization have been previously reported. Finally we realized the Layer by Layer (LbL) build-up of the PEM coating onto the textile support, using the dip coating method, by alternatively soaking it in cationic polyEPG-CD and anionic polyCTR-CD solutions. This multilayer self-assembly was monitored by SEM, gravimetry and OWLS in function of both polyelectrolytes concentrations and ratios. Solutions parameters such as pH, ionic strenght were also discussed.
基于阳离子和阴离子β-环糊精聚合物的聚电解质多层膜（PEM）被涂覆到纺织基底上，用于未来的药物输送目的。我们首先通过在碱性条件下用环氧氯丙烷（EP）交联β-环糊精（βCD），并使用氯化三甲基烯丙基铵（GTMAC）作为阳离子化基团，合成了一种新型阳离子β-环糊精聚合物（polyEPG-CD）。为了优选获得用于层层（LbL）沉积过程的最佳电荷密度和分子量的水溶性级分，研究了制备条件的影响。通过 FTIR、NMR、胶体滴定、电导率、热重分析和尺寸排阻色谱对得到的不同阳离子环糊精聚合物进行了表征。此外，对应的聚电解质是用柠檬酸交联的β-环糊精聚合物，即 polyCTR-CD，其合成和表征先前已有报道。最后，我们使用浸涂法，通过交替浸泡在阳离子 polyEPG-CD 和阴离子 polyCTR-CD 溶液中，在纺织基底上实现 PEM 涂层的层层（LbL）构建。通过 SEM、重量法和 OWLS 监测了多层自组装过程，同时还研究了两种聚电解质浓度和比例的影响。还讨论了溶液参数，如 pH 值和离子强度。
