Li Yu-Feng, Zhao Jiating, Qu Ying, Gao Yuxi, Guo Zhenghang, Liu Zuoliang, Zhao Yuliang, Chen Chunying
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and Laboratory of Metallomics and Nanometallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China.
Nanomedicine. 2015 Aug;11(6):1531-49. doi: 10.1016/j.nano.2015.04.008. Epub 2015 Apr 29.
Nanotoxicology studies the interactions of engineered nanomaterials with biological systems. Traditional in vitro and in vivo toxicological assays have been successfully employed. However, the toxicological mechanisms of nanoparticles might not be the same as those incurred in traditional molecular toxicology. Furthermore, how to realize in situ and real time measurements especially in the biological microenvironment is still a challenge. Synchrotron radiation, which is highly polarized and tunable, has been proved to play an indispensible role for nanotoxicology studies. In this review, the role of synchrotron radiation techniques is summarized in screening physicochemical characteristics, in vitro and in vivo behaviors, and ecotoxicological effects of engineered nanomaterials.
The rapid gain in popularity of nanomaterials has also raised the concern of nanotoxicity, which needs to be assessed and addressed. In this comprehensive review, the authors outlined the underlying principles of using synchrotron radiation techniques for nanotoxicology studies and also in other scientific fields.
纳米毒理学研究工程纳米材料与生物系统的相互作用。传统的体外和体内毒理学检测方法已得到成功应用。然而，纳米颗粒的毒理学机制可能与传统分子毒理学中的机制不同。此外，如何实现原位和实时测量，尤其是在生物微环境中，仍然是一个挑战。同步辐射具有高度极化和可调谐性，已被证明在纳米毒理学研究中发挥着不可或缺的作用。在本综述中，总结了同步辐射技术在筛选工程纳米材料的物理化学特性、体外和体内行为以及生态毒理学效应方面的作用。
纳米材料的迅速普及也引发了对纳米毒性的关注，这需要进行评估和解决。在这篇全面的综述中，作者概述了在纳米毒理学研究以及其他科学领域中使用同步辐射技术的基本原理。
