Nagaoka A, Shibota M
Development Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
Jpn J Pharmacol. 1989 Oct;51(2):299-301. doi: 10.1254/jjp.51.299.
Effects of manidipine, a new dihydropyridine derivative, on sodium and water excretion were examined in conscious spontaneously hypertensive rats. Manidipine (3 mg/kg) significantly increased the sodium and water excretion in the urine collected for 3 hr after the calcium antagonist was orally administered, and its natriuretic action was more prominent than those of nifedipine and nicardipine (3 mg/kg). These results suggest that manidipine may be useful for treating hypertension.
在清醒的自发性高血压大鼠中研究了新型二氢吡啶衍生物马尼地平对钠和水排泄的影响。口服给予钙拮抗剂后，马尼地平（3毫克/千克）显著增加了3小时收集尿液中的钠和水排泄，其利钠作用比硝苯地平和尼卡地平（3毫克/千克）更显著。这些结果表明，马尼地平可能对治疗高血压有用。
