大鼠嘴侧无颗粒岛叶皮质在尼古丁自我给药中的作用。
Involvement of the rostral agranular insular cortex in nicotine self-administration in rats.
作者信息
Pushparaj Abhiram, Kim Aaron S, Musiol Martin, Trigo Jose M, Le Foll Bernard
机构信息
Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada; Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
出版信息
Behav Brain Res. 2015 Sep 1;290:77-83. doi: 10.1016/j.bbr.2015.04.039. Epub 2015 Apr 28.
Our prior work demonstrated the involvement of the caudal granular subregion of the insular cortex in a rat model of nicotine self-administration. Recent studies in various animal models of addiction for nicotine and other drugs have identified a role for the rostral agranular subregion (RAIC). The current research was undertaken to examine the involvement of the RAIC in a rat model of nicotine self-administration. We investigated the inactivating effects of local infusions of a γ-aminobutyric acid agonist mixture (baclofen/muscimol) into the RAIC on nicotine self-administration under a fixed-ratio 5 (FR-5) schedule and on reinstatement of nicotine seeking induced by nicotine-associated cues in rats. We also evaluated the effects of RAIC inactivation on food self-administration under an FR5 schedule as a control. Inactivation of the RAIC decreased nicotine, but not food, self-administration. RAIC inactivation also prevented the reinstatement, after extinction, of nicotine seeking induced by nicotine-associated cues. Our study indicates that the RAIC is involved in nicotine-taking and nicotine-seeking in rats. Modulating insular cortex function appears to be a promising approach for nicotine dependence treatment.
我们之前的研究表明，岛叶皮质尾侧颗粒亚区参与了大鼠尼古丁自我给药模型。最近在尼古丁及其他药物成瘾的各种动物模型中的研究确定了嘴侧无颗粒亚区（RAIC）的作用。当前的研究旨在探讨RAIC在大鼠尼古丁自我给药模型中的参与情况。我们研究了在固定比率5（FR-5）方案下，向RAIC局部注射γ-氨基丁酸激动剂混合物（巴氯芬/蝇蕈醇）对大鼠尼古丁自我给药以及尼古丁相关线索诱导的尼古丁寻求恢复的失活作用。我们还评估了RAIC失活作为对照对FR5方案下食物自我给药的影响。RAIC失活减少了尼古丁自我给药，但未减少食物自我给药。RAIC失活还阻止了消退后由尼古丁相关线索诱导的尼古丁寻求的恢复。我们的研究表明，RAIC参与了大鼠的尼古丁摄取和尼古丁寻求。调节岛叶皮质功能似乎是治疗尼古丁依赖的一种有前景的方法。
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