Binder Pratibha S, Prat Jaime, Mutch David G
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Department of Pathology, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.
Best Pract Res Clin Obstet Gynaecol. 2015 Aug;29(6):776-89. doi: 10.1016/j.bpobgyn.2015.01.008. Epub 2015 Mar 4.
The purpose of cancer staging is to classify cancers into prognostic groups and to allow for comparison of treatment results and survival between patients and institutions. Staging for gynecologic cancers is based on extent of disease and metastasis, which was historically determined by physical examination and is now based on surgical and histologic examination of tumor specimens. Although the extent of disease is currently considered the most important predictor of recurrence and survival, current staging does not include molecular features that are associated with tumor aggressiveness, response to therapy, and prognosis. This review focuses on genomic and proteomic features of gynecologic cancers and the future of biomarkers in staging classification.
癌症分期的目的是将癌症分类为不同的预后组,并便于比较患者和机构之间的治疗结果及生存率。妇科癌症的分期基于疾病范围和转移情况,这在历史上是通过体格检查确定的,而现在则基于肿瘤标本的手术和组织学检查。尽管目前疾病范围被认为是复发和生存的最重要预测因素,但当前的分期并不包括与肿瘤侵袭性、对治疗的反应及预后相关的分子特征。本综述重点关注妇科癌症的基因组和蛋白质组特征以及生物标志物在分期分类中的未来发展。