Hirano S, Ito N, Takahashi S, Tamaya T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu, Japan.
Eur J Gynaecol Oncol. 2004;25(2):187-91.
Since insulin-like growth factors (IGFs) are known to play critical roles in the development of cancers, we examined the expression of the mRNA and protein of IGF-binding protein (IGFBP) and cognate receptors to assess their possible involvement in gynecological malignancy. The specimens were obtained from 46 endometrial, 32 cervical, and 20 ovarian cancers, and 28 normal endometrium. In endometrial cancers, IGFBP-1, -2, -3 and IGF-1 receptor (IGF-1R) mRNAs were detected in 8.7, 89.1, 95.6, and 91.3% of tumors, respectively, and the corresponding proteins in 54.3, 54.3, 95.6, and 91.3% of tumors, respectively. Clinical staging was significantly related to the expression of IGFBP-1 and -2 proteins. In ovarian cancers, their mRNAs were detected in 10.0, 90.0, 95.0, and 100.0%, and proteins in 15.9, 50.0, 90.0, and 80.0%. In cervical cancers, their mRNAs were detected in 6.3, 90.6, 96.8, and 87.5%, and proteins in 44.4, 18.8, 84.4, and 87.5%. IGF-1R was highly expressed in all specimens. The abnormally balanced co-expression of IGFBPs and high levels of IGF-R in gynecological cancers suggest that IGF signals might be involved in the growth of these tumors.
由于胰岛素样生长因子（IGFs）在癌症发展中发挥关键作用，我们检测了胰岛素样生长因子结合蛋白（IGFBP）及其同源受体的mRNA和蛋白表达，以评估它们在妇科恶性肿瘤中的可能作用。标本取自46例子宫内膜癌、32例宫颈癌和20例卵巢癌以及28例正常子宫内膜。在子宫内膜癌中，分别在8.7%、89.1%、95.6%和91.3%的肿瘤中检测到IGFBP-1、-2、-3和胰岛素样生长因子-1受体（IGF-1R）的mRNA，相应蛋白分别在54.3%、54.3%、95.6%和91.3%的肿瘤中检测到。临床分期与IGFBP-1和-2蛋白的表达显著相关。在卵巢癌中，它们的mRNA分别在10.0%、90.0%、95.0%和100.0%的肿瘤中检测到，蛋白分别在15.9%、50.0%、90.0%和80.0%的肿瘤中检测到。在宫颈癌中，它们的mRNA分别在6.3%、90.6%、96.8%和87.5%的肿瘤中检测到，蛋白分别在44.4%、18.8%、84.4%和87.5%的肿瘤中检测到。IGF-1R在所有标本中均高表达。妇科癌症中IGFBPs的异常平衡共表达和高水平的IGF-R表明IGF信号可能参与这些肿瘤的生长。
