Doré V, Dubuc J, Bélanger A M, Buczinski S
Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, C.P. 5000, Université de Montréal, Saint-Hyacinthe, Québec, J2S 7C6, Canada.
Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, C.P. 5000, Université de Montréal, Saint-Hyacinthe, Québec, J2S 7C6, Canada.
J Dairy Sci. 2015 Jul;98(7):4535-43. doi: 10.3168/jds.2014-9172. Epub 2015 Apr 29.
A prospective cohort study was conducted on 1,081 dairy goats from 10 commercial herds in Québec (Canada) to define prepartum hyperketonemia based on optimal blood β-hydroxybutyrate acid threshold values for the early prediction of pregnancy toxemia (PT) and mortality in late-gestation dairy goats. All pregnant goats had blood sampled weekly during the last 5wk of pregnancy. The blood was analyzed directly on the farm for β-hydroxybutyrate acid quantification using a Precision Xtra meter (Abbott Diabetes Care, Saint-Laurent, QC, Canada). Body condition scores on the lumbar region and sternum were noted. Each goat was classified as being at low (n=973) or high risk (n=108) of having PT by producers based on a standardized definition. The optimal threshold for predicting a PT diagnosis or mortality for each week before kidding was determined based on the highest sum of sensitivity and specificity. The association between hyperketonemia and subsequent PT was tested using a multivariable logistic regression model considering hyperketonemia at wk 4 prepartum, litter size, and body condition score at wk 4 prepartum as covariates, and herd and parturition cohort as random effects. The association between mortality and hyperketonemia was also tested using a logistic regression model accounting for the presence or absence of treatment during the last month of pregnancy. The hyperketonemia definition based on PT varied between ≥0.4 and ≥0.9mmol/L during the last 5wk prepartum. Goats affected by hyperketonemia at wk 4 prepartum and with a large litter size (≥3 fetuses) had 2.1 and 40.5 times the odds, respectively, of subsequent PT than other goats. Hyperketonemia definitions based on mortality varied between ≥0.6 and ≥1.4mmol/L during the last 4wk prepartum, and was ≥1.7mmol/L during the first week postpartum. Goats affected by hyperketonemia and treated by producers had 3.4 and 11.8 times the odds, respectively, of subsequent mortality than did other goats. These results showed that prepartum hyperketonemia could be defined in dairy goats using subsequent risks of PT or mortality during the last month of pregnancy.
对加拿大魁北克10个商业养殖场的1081只奶山羊进行了一项前瞻性队列研究，以根据最佳血液β-羟基丁酸阈值来定义产前高酮血症，从而早期预测妊娠毒血症（PT）和妊娠后期奶山羊的死亡率。所有怀孕山羊在妊娠最后5周每周采血。使用Precision Xtra血糖仪（雅培糖尿病护理公司，加拿大魁北克省圣洛朗）在农场直接分析血液中的β-羟基丁酸含量。记录腰椎和胸骨的体况评分。根据标准化定义，生产者将每只山羊分为发生PT的低风险（n = 973）或高风险（n = 108）。根据敏感性和特异性的最高总和，确定产羔前每周预测PT诊断或死亡率的最佳阈值。使用多变量逻辑回归模型测试高酮血症与随后PT之间的关联，该模型将产前第4周的高酮血症、产仔数和产前第4周的体况评分作为协变量，并将养殖场和分娩队列作为随机效应。还使用逻辑回归模型测试死亡率与高酮血症之间的关联，该模型考虑了妊娠最后一个月是否接受治疗。产前最后5周基于PT的高酮血症定义在≥0.4至≥0.9mmol/L之间变化。产前第4周受高酮血症影响且产仔数多（≥3只胎儿）的山羊随后发生PT的几率分别是其他山羊的2.1倍和40.5倍。产前最后4周基于死亡率的高酮血症定义在≥0.6至≥1.4mmol/L之间变化，产后第一周≥1.7mmol/L。受高酮血症影响并由生产者进行治疗的山羊随后死亡的几率分别是其他山羊的3.4倍和11.8倍。这些结果表明，可以利用妊娠最后一个月PT或死亡的后续风险来定义奶山羊的产前高酮血症。
