Wei H L, An J, Zeng L L, Shen H, Qiu S J, Hu D W
College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, People's Republic of China.
Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
Epilepsy Behav. 2015 May;46:118-25. doi: 10.1016/j.yebeh.2015.03.031. Epub 2015 Apr 30.
Numerous resting-state fMRI studies have demonstrated altered functional connectivity within canonical intrinsic connectivity networks (ICNs) in patients with idiopathic generalized epilepsy (IGE). It is possible that the widespread ICN abnormalities on electroencephalography in IGE derive from abnormal functional interactions between ICNs. To test this possibility, we explored the functional connectivity between the subnetworks of the default mode network (DMN), attention network (ATN), and frontoparietal control network (FPN) using independent component analysis of resting-state fMRI data collected from 27 patients with IGE characterized by generalized tonic-clonic seizures (GTCS) and 29 matched healthy controls. It was observed that the left FPN exhibited increased connectivity with the anterior DMN and ventral ATN, while the right FPN exhibited increased connectivity with the anterior and posterior DMNs in the patients with IGE-GTCS. Furthermore, the functional connectivity between the anterior DMN and ventral ATN was negative in healthy controls but positive in the patients with IGE-GTCS. In addition, the anterior DMN exhibited increased intranetwork functional connectivity in the right frontal pole in IGE-GTCS. These findings suggest that IGE-GTCS is likely associated with a disrupted brain organization probably derived from abnormal functional interactions among ICNs. Furthermore, the alterations in the functional architecture of the ICNs may be related to deficits in mentation and attention in IGE-GTCS, providing informative evidence for the understanding of the pathophysiology of IGE-GTCS.
众多静息态功能磁共振成像（fMRI）研究表明，特发性全身性癫痫（IGE）患者的典型内在连接网络（ICN）内的功能连接发生了改变。IGE患者脑电图上广泛的ICN异常可能源于ICN之间异常的功能相互作用。为了验证这种可能性，我们使用独立成分分析，对27例以全身强直阵挛性发作（GTCS）为特征的IGE患者和29名匹配的健康对照者采集的静息态fMRI数据进行分析，探索默认模式网络（DMN）、注意力网络（ATN）和额顶叶控制网络（FPN）子网之间的功能连接。结果发现，在IGE-GTCS患者中，左侧FPN与前DMN和腹侧ATN的连接性增加，而右侧FPN与前、后DMN的连接性增加。此外，前DMN与腹侧ATN之间的功能连接在健康对照者中为负，而在IGE-GTCS患者中为正。另外，在IGE-GTCS患者中，前DMN在右侧额极的网络内功能连接增加。这些发现表明，IGE-GTCS可能与大脑组织紊乱有关，这可能源于ICN之间异常的功能相互作用。此外，ICN功能结构的改变可能与IGE-GTCS患者的精神状态和注意力缺陷有关，为理解IGE-GTCS的病理生理学提供了有益的证据。
