Gay André, Aimonetti Jean-Marc, Roll Jean-Pierre, Ribot-Ciscar Edith
La Conception Hospital, APHM, Marseille, France.
Aix-Marseille université, CNRS, NIA UMR 7260, 13331 Marseille, France.
Brain Res. 2015 Jul 30;1615:148-156. doi: 10.1016/j.brainres.2015.04.041. Epub 2015 Apr 29.
In the present study, muscle pain was induced experimentally in healthy subjects by administrating hypertonic saline injections into the tibialis anterior (TA) muscle. We first aimed at comparing the analgesic effects of mechanical vibration applied to either cutaneous or muscle receptors of the TA or to both types simultaneously. Secondly, pain alleviation was compared in subjects in whom muscle tendon vibration evoked kinesthetic illusions of the ankle joint. Muscle tendon vibration, which primarily activated muscle receptors, reduced pain intensity by 30% (p<0.01). In addition, tangential skin vibration reduced pain intensity by 33% (p<0.01), primarily by activating cutaneous receptors. Concurrently stimulating both sensory channels induced stronger analgesic effects (-51%, p<0.01), as shown by the lower levels of electrodermal activity. The strongest analgesic effects of the vibration-induced muscle inputs occurred when illusory movements were perceived (-38%, p=0.01). The results suggest that both cutaneous and muscle sensory feedback reduce muscle pain, most likely via segmental and supraspinal processes. Further clinical trials are needed to investigate these new methods of muscle pain relief.
在本研究中，通过向健康受试者的胫骨前肌（TA）注射高渗盐水来实验性诱导肌肉疼痛。我们首先旨在比较施加于TA的皮肤或肌肉感受器或同时施加于两种类型感受器的机械振动的镇痛效果。其次，比较了肌肉肌腱振动诱发踝关节动觉错觉的受试者的疼痛缓解情况。主要激活肌肉感受器的肌肉肌腱振动使疼痛强度降低了30%（p<0.01）。此外，切向皮肤振动主要通过激活皮肤感受器使疼痛强度降低了33%（p<0.01）。同时刺激两种感觉通道可诱导更强的镇痛效果（-51%，p<0.01），这可通过较低水平的皮肤电活动表现出来。当感觉到虚幻运动时，振动诱发的肌肉输入产生的镇痛效果最强（-38%，p=0.01）。结果表明，皮肤和肌肉感觉反馈最有可能通过节段性和脊髓上的过程减轻肌肉疼痛。需要进一步的临床试验来研究这些缓解肌肉疼痛的新方法。
