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Trends in the evidence level for the American Diabetes Association's "Standards of Medical Care in Diabetes" from 2005 to 2014.2005年至2014年美国糖尿病协会《糖尿病医疗护理标准》的证据水平趋势。
Diabetes Care. 2015 Jan;38(1):6-8. doi: 10.2337/dc14-2142.
2
The relationship between epicardial fat thickness and gestational diabetes mellitus.心外膜脂肪厚度与妊娠期糖尿病之间的关系。
Diabetol Metab Syndr. 2014 Nov 6;6(1):120. doi: 10.1186/1758-5996-6-120. eCollection 2014.
3
Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.在普通人群中，循环脂肪酸结合蛋白4水平升高与左心室舒张功能障碍独立相关。
Cardiovasc Diabetol. 2014 Aug 21;13:126. doi: 10.1186/s12933-014-0126-7.
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2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).2014 年成人高血压管理的循证指南：第八届联合国家委员会（JNC 8）任命的专家组报告。
JAMA. 2014 Feb 5;311(5):507-20. doi: 10.1001/jama.2013.284427.
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Accumulation of epicardial fat rather than visceral fat is an independent risk factor for left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis.心包脂肪堆积而非内脏脂肪堆积是腹膜透析患者左心室舒张功能障碍的独立危险因素。
Cardiovasc Diabetol. 2013 Aug 30;12:127. doi: 10.1186/1475-2840-12-127.
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Epicardial fat: definition, measurements and systematic review of main outcomes.心外膜脂肪：定义、测量方法和主要结局的系统评价。
Arq Bras Cardiol. 2013 Jul;101(1):e18-28. doi: 10.5935/abc.20130138.
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Quantification of epicardial adipose tissue: correlation of surface area and volume measurements.心外膜脂肪组织定量：表面积和体积测量的相关性。
Acad Radiol. 2011 Aug;18(8):977-83. doi: 10.1016/j.acra.2011.03.011. Epub 2011 Jun 11.
8
Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue.冠心病与心外膜组织中的视黄醇结合蛋白 4（RBP4）水平升高和葡萄糖转运蛋白（GLUT）4 水平降低有关。
Clin Endocrinol (Oxf). 2012 Jan;76(1):51-8. doi: 10.1111/j.1365-2265.2011.04140.x.
9
Interscan reproducibility of computer-aided epicardial and thoracic fat measurement from noncontrast cardiac CT.非增强心脏 CT 计算机辅助心外膜和胸腔脂肪测量的 Interscan 可重复性。
J Cardiovasc Comput Tomogr. 2011 May-Jun;5(3):172-9. doi: 10.1016/j.jcct.2011.03.009. Epub 2011 Mar 21.
10
Relationship between epicardial fat measured by 64-multidetector computed tomography and coronary artery disease.64 层多排 CT 测量的心外膜脂肪与冠状动脉疾病的关系。
Clin Cardiol. 2011 Mar;34(3):166-71. doi: 10.1002/clc.20840. Epub 2011 Feb 1.

韩国男性的心外膜脂肪厚度与2型糖尿病相关：一项横断面研究。

Epicardial fat thickness is associated to type 2 diabetes mellitus in Korean men: a cross-sectional study.

作者信息

Chun Hyejin, Suh Eunkyung, Byun A Ri, Park Hae Ran, Shim Kyung Won

机构信息

Health Promotion Center, Ewha Womans University Mokdong hospital, Ewha Womans University School of Medicine, Anyangcheon-ro, Yangcheon-gu, Seoul, 158-710, South Korea.

Department of Family Medicine, Chaum Hospital, CHA University, 4-1, Cheongdam-dong, Gangnam-gu, Seoul, 135-948, South Korea.

出版信息

Cardiovasc Diabetol. 2015 May 3;14:46. doi: 10.1186/s12933-015-0210-7.

DOI:10.1186/s12933-015-0210-7
PMID:25935836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4432519/
Abstract

BACKGROUND

Visceral fat, including epicardial fat (EF) is recognized as a responsible factor of cardiovascular disease. The aim of this study was to investigate the relationship between EF and diabetes in Korean men.

METHODS

EF thickness was measured in the left main coronary artery fat tissue (LMCA-fat) by low-dose chest CT scans in 1,048 Korean men (age above 20 years). LMCA-fat values were divided into quartiles and the prevalence of diabetes was analyzed based on the quartiles of LMCA-fat values using logistic regression.

RESULTS

There were significant correlations between LMCA-fat and body mass index (r = 0.169, p = 0.004), waist circumference (r = 0.172, p < 0.001), fasting glucose (r = 0.106, p = 0.037) and HbA1c (r = 0.176, p < 0.001). The patients in the higher LMCA-fat quartiles were associated with higher prevalence of diabetes (p for trend <0.001). Even after adjustment for multiple covariates, this association still remained statistically significant (p for trend = 0.022). The highest LMCA-fat quartile group was significantly associated with diabetes compared to the lowest quartile group. (OR = 3.26, 95% CI = 1.17-9.12).

CONCLUSION

These findings indicate that increased EF thickness is independently associated with the prevalence of diabetes in Korean men.

摘要

背景

包括心外膜脂肪（EF）在内的内脏脂肪被认为是心血管疾病的一个致病因素。本研究的目的是调查韩国男性中EF与糖尿病之间的关系。

方法

通过低剂量胸部CT扫描测量了1048名韩国男性（年龄在20岁以上）左主干冠状动脉脂肪组织（LMCA-脂肪）中的EF厚度。将LMCA-脂肪值分为四分位数，并使用逻辑回归分析基于LMCA-脂肪值四分位数的糖尿病患病率。

结果

LMCA-脂肪与体重指数（r = 0.169，p = 0.004）、腰围（r = 0.172，p < 0.001）、空腹血糖（r = 0.106，p = 0.037）和糖化血红蛋白（r = 0.176，p < 0.001）之间存在显著相关性。LMCA-脂肪四分位数较高的患者糖尿病患病率较高（趋势p < 0.001）。即使在对多个协变量进行调整后，这种关联仍然具有统计学意义（趋势p = 0.022）。与最低四分位数组相比，最高LMCA-脂肪四分位数组与糖尿病显著相关（OR = 3.26，95%CI = 1.17 - 9.12）。

结论

这些发现表明，EF厚度增加与韩国男性糖尿病患病率独立相关。