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创伤后癫痫:一项多中心流行病学研究。

Post-traumatic seizure: a multicentric epidemiological study.

作者信息

Bhattacharyya Kalishankar, Mandal Nikhilesh, Paul Uttam Kumar, Bhattacharyya Anup Kumar, Sinharay Keshab, Gantait Kripasindhu

出版信息

J Indian Med Assoc. 2014 Feb;112(2):93-5.

Abstract

Post-traumatic seizure (PTS) is the development of recurrent seizures following head trauma and has a high clinical relevance. We tried to understand the epidemiology of PTS in a multicentric pro- spective study during the period May 2010 to April 2012. We included 320 patients excluding poor Glasgow coma scale (GCS) ie, <4 and history of previous epilepsy. At a median follow-up of one year, 49 patients (15.31%) developed PTS. Incidence of immediate, early and late onset seizures were 27 (8.4%), 14 (4.4%), 9 (2.8%) respectively. In this study incidence of PTS was high in patients of the age group 20-30 years, with road traffic accident, with poor GCS ie, < 9. High incidence of PTS was associated with x- ray findings of skull fracture and abnormal CT findings. Early use of anticonvulsants is ineffective in preventing early post-traumatic epilepsy.

摘要

创伤后癫痫(PTS)是头部创伤后反复发生癫痫的情况,具有高度的临床相关性。在2010年5月至2012年4月期间,我们通过一项多中心前瞻性研究试图了解PTS的流行病学情况。我们纳入了320例患者,排除格拉斯哥昏迷量表(GCS)评分低(即<4分)以及既往有癫痫病史的患者。在中位随访一年时,49例患者(15.31%)发生了PTS。即刻、早期和晚期发作癫痫的发生率分别为27例(8.4%)、14例(4.4%)、9例(2.8%)。在本研究中,年龄在20 - 30岁、因道路交通事故致伤、GCS评分低(即<9分)的患者中PTS发生率较高。PTS的高发生率与颅骨骨折的X线表现及CT异常表现相关。早期使用抗惊厥药物在预防创伤后早期癫痫方面无效。

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