Wang Hung-Chen, Chang Wen-Neng, Chang Hsueh-Wen, Ho Jih-Tsun, Yang Tzu-Ming, Lin Wei-Che, Chuang Yao-Chung, Lu Cheng-Hsien
Departments of Neurosurgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, China.
J Trauma. 2008 Apr;64(4):883-8. doi: 10.1097/TA.0b013e31804a7fa4.
Seizures are important neurologic complications of traumatic brain injury (TBI). There is a need for better delineation of potential prognostic factors and outcomes in patients with posttraumatic seizures (PTS) who could receive treatment when brought to the hospital.
In this 10-year retrospective study, 170 adult patients with PTS were enrolled in this study. The degree of seizure control was analyzed using a Seizure Frequency Scoring System, which classified them into excellent and nonexcellent outcomes.
There were 170 patients with acute symptomatic seizure enrolled in this study, 106 of whom had early PTS, whereas 64 had late PTS. Of the 106 early PTS, 58% (61 of 106) occurred within 24 hours of trauma. Risk factors for developing nonexcellent outcome included patients who undergo surgical intervention and presence of late-provoked seizures during the acute phase of TBI.
Seizures are an important neurologic complication of TBI. Regarding the potentially side effects of antiepileptic drugs, antiepileptic therapy should be carefully administrated in those nonexcellent outcome patients.
癫痫发作是创伤性脑损伤（TBI）重要的神经并发症。对于创伤后癫痫（PTS）患者，在其被送至医院时，需要更好地明确潜在的预后因素及结果，以便进行治疗。
在这项为期10年的回顾性研究中，170例成年PTS患者被纳入研究。使用癫痫发作频率评分系统分析癫痫控制程度，将其分为良好和非良好结局。
本研究纳入170例急性症状性癫痫患者，其中106例为早期PTS，64例为晚期PTS。在106例早期PTS中，58%（106例中的61例）在创伤后24小时内发作。非良好结局的危险因素包括接受手术干预的患者以及TBI急性期出现晚期诱发癫痫。
癫痫发作是TBI的重要神经并发症。鉴于抗癫痫药物可能存在的副作用，对于非良好结局的患者应谨慎给予抗癫痫治疗。
