Ochiai Moeko, Yamanaka Hisashi
Nihon Rinsho. 2015 Apr;73(4):644-8.
Recently a concept of "sex differences" in medicine has been spreading. It is well known that autoimmune diseases, especially rheumatoid arthritis or systemic lupus erythematosus mostly affect women, and it is clear that there is a strong sex differences in many rheumatic diseases. Sex difference influences to progression or prognosis of the disease. Although the mechanisms of sex difference are not clear, the influence of sex hormones or sex chromosomes which gives immune system is partially elucidated. In addition, sex hormones may become the future new treatment target, and progress in the study regarding this event is expected in the future.
最近，医学领域中“性别差异”的概念正在广泛传播。众所周知，自身免疫性疾病，尤其是类风湿性关节炎或系统性红斑狼疮大多影响女性，而且很明显在许多风湿性疾病中存在强烈的性别差异。性别差异会影响疾病的进展或预后。虽然性别差异的机制尚不清楚，但已部分阐明了给予免疫系统的性激素或性染色体的影响。此外，性激素可能成为未来新的治疗靶点，预计未来在这方面的研究将取得进展。
