Slattum M M, Tsai C C, DiGiacomo R F, Giddens W E
Division of Animal Medicine, School of Medicine, University of Washington, Seattle 98195.
Lab Anim Sci. 1989 Nov;39(6):567-70.
The pathologic aspects of 248 cases of amyloidosis in pigtailed macaques (Macaca nemestrina) at the Washington Regional Primate Research Center from 1971 through 1985 were studied. Amyloid was present in the spleen, liver and gastrointestinal (GI) tract, either alone or in combination, in nearly 75% of the monkeys. Its occurrence declined with age in the spleen and the GI tract, but increased with age in the liver. Both intestinal inflammation and retroperitoneal fibromatosis were strongly associated with amyloid deposition in the GI tract. Monkeys with histopathologic findings of enteritis or enterocolitis and glomerulonephritis were at increased risk of developing amyloidosis. Forty cases of amyloidosis with a history of chronic diarrhea had type AA amyloid by histochemical tests.
对华盛顿地区灵长类动物研究中心1971年至1985年间248例豚尾猕猴（食蟹猴）淀粉样变性的病理情况进行了研究。近75%的猴子脾脏、肝脏和胃肠道单独或联合出现淀粉样物质。其在脾脏和胃肠道的发生率随年龄下降，但在肝脏中随年龄增加。肠道炎症和腹膜后纤维瘤病均与胃肠道淀粉样沉积密切相关。有肠炎或小肠结肠炎及肾小球肾炎组织病理学表现的猴子发生淀粉样变性的风险增加。40例有慢性腹泻病史的淀粉样变性病例经组织化学检测为AA型淀粉样蛋白。
