Oregon National Primate Research Center, Beaverton, Oregon, USA.
Charles River Laboratories, Reno, Nevada, USA.
Toxicol Pathol. 2022 Jul;50(5):638-659. doi: 10.1177/01926233221084634. Epub 2022 Apr 1.
Rhesus and cynomolgus macaques are the most frequently used nonhuman primate (NHP) species for biomedical research and toxicology studies of novel therapeutics. In recent years, there has been a shortage of laboratory macaques due to a variety of competing factors. This was most recently exacerbated by the surge in NHP research required to address the severe acute respiratory syndrome (SARS)-coronavirus 2 pandemic. Continued support of these important studies has required the use of more varied cohorts of macaques, including animals with different origins, increased exposure to naturally occurring pathogens, and a wider age range. Diarrhea and diseases of the gastrointestinal tract are the most frequently occurring spontaneous findings in macaques of all origins and ages. The purpose of this review is to alert pathologists and scientists involved in NHP research to these findings and their impact on animal health and study endpoints, which may otherwise confound the interpretation of data generated using macaques.
恒河猴和食蟹猴是用于生物医学研究和新型治疗药物毒理学研究的最常使用的非人类灵长类动物（NHP）物种。近年来，由于各种竞争因素，实验室恒河猴和食蟹猴的数量短缺。最近，由于需要大量的 NHP 研究来应对严重急性呼吸综合征（SARS）-冠状病毒 2 大流行，这种情况更加恶化。要继续支持这些重要的研究，就需要使用更多不同来源的恒河猴和食蟹猴群体，包括来自不同来源的动物、增加对天然病原体的暴露以及更广泛的年龄范围。腹泻和胃肠道疾病是所有来源和年龄段的恒河猴和食蟹猴最常发生的自发性发现。本文的目的是提醒参与 NHP 研究的病理学家和科学家注意这些发现及其对动物健康和研究终点的影响，否则这些影响可能会混淆使用恒河猴和食蟹猴产生的数据的解释。
