Coulson N M, Januszkiewicz A J, Dodd K T, Ripple G R
Royal Army Veterinary Corps, Aldershot, England.
Lab Anim Sci. 1989 Nov;39(6):591-7.
The cardiorespiratory dynamics and anesthetic effects of intravenously administered diazepam-ketamine (0.375 mg kg-1/7.5 mg kg-1) and xylazine-ketamine (0.1 mg kg-1/7.5 mg kg-1) were investigated in six domestic sheep (Ovis aries). The depth of analgesia and sedation was evaluated and the effects of the anesthetic drug combinations on hemodynamics and pulmonary mechanics were monitored before, and up to 90 minutes after, drug administration. Diazepam-ketamine and xylazine-ketamine induced effective anesthesia for periods lasting 15 minutes and 25 minutes, respectively. Both drug combinations caused transient respiratory acidosis. However, no profound effects on respiration or pulmonary function were observed. Neither anesthetic regimen caused significant effects on heart rate or pulmonary hemodynamics, but they caused significant decreases in cardiac output. Xylazine-ketamine resulted in a significant decrease in mean systemic arterial blood pressure (Psa) with a concurrent decrease in systemic vascular resistance (SVR). Diazepam-ketamine caused a significant increase in SVR without affecting Psa. Xylazine-ketamine may be contraindicated in animals with compromised heart function because of its hypotensive effects. Otherwise, both drug combinations, in the doses used, can provide short-term anesthesia suitable for minor surgical procedures and painful experimental maneuvers.
研究了静脉注射地西泮 - 氯胺酮（0.375毫克/千克 - 7.5毫克/千克）和赛拉嗪 - 氯胺酮（0.1毫克/千克 - 7.5毫克/千克）对6只家羊（绵羊）的心肺动力学及麻醉效果。在给药前及给药后长达90分钟内，评估镇痛和镇静深度，并监测麻醉药物组合对血流动力学和肺力学的影响。地西泮 - 氯胺酮和赛拉嗪 - 氯胺酮分别诱导有效麻醉持续15分钟和25分钟。两种药物组合均引起短暂性呼吸性酸中毒。然而，未观察到对呼吸或肺功能的深远影响。两种麻醉方案均未对心率或肺血流动力学产生显著影响，但均导致心输出量显著降低。赛拉嗪 - 氯胺酮导致平均体循环动脉血压（Psa）显著降低，同时体循环血管阻力（SVR）降低。地西泮 - 氯胺酮导致SVR显著增加而不影响Psa。由于其降压作用，赛拉嗪 - 氯胺酮可能对心功能受损的动物禁用。否则，所使用剂量的两种药物组合均可提供适用于小型外科手术和疼痛性实验操作的短期麻醉。
