内脂素的促炎作用进展及其与糖尿病肾病的关系
Advances in the proinflammatory effects of visfatin and its relationship with diabetic kidney disease.
作者信息
Zhang Liang-yan, Li Xue-mei
机构信息
Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Apr;37(2):246-52. doi: 10.3881/j.issn.1000-503X.2015.02.019.
Visfatin, also known as the pre-B-cell colony enhancing factor, is a new member of the adipocytokines. It serves as a nicotinamide phosphoribosyltransferase in cells. Visfatin has complex biological functions and may be involved in the pathogenesis of diabetic kidney disease; it may contribute to the chronic inflammatory status at systemic and renal levels and thus aggravate renal injury. Further research on visfatin will provide new insights in the treatment of diabetic kidney disease. This article reviews the recent advances in the proinflammatory effects of visfatin and its relationship with diabetic kidney disease.
内脂素，也被称为前B细胞集落增强因子，是脂肪细胞因子的一个新成员。它在细胞中作为烟酰胺磷酸核糖基转移酶发挥作用。内脂素具有复杂的生物学功能，可能参与糖尿病肾病的发病机制；它可能在全身和肾脏水平促成慢性炎症状态，从而加重肾损伤。对内脂素的进一步研究将为糖尿病肾病的治疗提供新的见解。本文综述了内脂素促炎作用及其与糖尿病肾病关系的最新研究进展。
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