胰岛素与多巴胺信号通路在调控黑腹果蝇适应性中的相互作用。 - Suppr

Interplay of insulin and dopamine signaling pathways in the control of Drosophila melanogaster fitness.

作者信息

Rauschenbach I Yu, Karpova E K, Alekseev A A, Adonyeva N V, Shumnaya L V, Gruntenko N E

机构信息

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090, Russia,

出版信息

Dokl Biochem Biophys. 2015;461:135-8. doi: 10.1134/S1607672915020179. Epub 2015 May 5.

DOI:10.1134/S1607672915020179

PMID:25937233

Abstract

摘要

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Interplay of insulin and dopamine signaling pathways in the control of Drosophila melanogaster fitness.胰岛素与多巴胺信号通路在调控黑腹果蝇适应性中的相互作用。

Dokl Biochem Biophys. 2015;461:135-8. doi: 10.1134/S1607672915020179. Epub 2015 May 5.

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Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila.脑下垂体中叶特异性胆固醇调节元件结合蛋白（Hmgcr）通过胰岛素途径控制果蝇的运动活动和体型的性别二态性。

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A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.一种延长寿命并损害神经内分泌功能的突变型果蝇胰岛素受体同源物。

Science. 2001 Apr 6;292(5514):107-10. doi: 10.1126/science.1057987.

[The DD2R gene expression level in the corpus allatum affects the fitness of female Drosophila melanogaster].咽侧体中DD2R基因的表达水平影响雌性黑腹果蝇的适应性

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A heteroallelic Drosophila insulin-like receptor mutant and its use in validating physiological activities of food constituents.一种异源等位果蝇胰岛素样受体突变体及其在验证食物成分生理活性中的应用。

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Melting fat away in flies.在果蝇身上消耗脂肪。

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Regulation of Sleep by Insulin-like Peptide System in Drosophila melanogaster.果蝇胰岛素样肽系统对睡眠的调控。

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Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.结构变异在复杂性状中表现出广泛的等位基因异质性和表型变异。

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Regulation of insulin and adipokinetic hormone/glucagon production in flies.调控果蝇胰岛素和脂肪激素/胰高血糖素的产生。

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Social regulation of insulin signaling and the evolution of eusociality in ants.胰岛素信号的社会调控与蚂蚁社会性的进化。

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Aminergic Signaling Controls Ovarian Dormancy in Drosophila.胺能信号控制果蝇的卵巢休眠。

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Loss of rescues stem cell aging in germ line.生殖系丧失挽救干细胞衰老。

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Disruption of dopamine homeostasis has sexually dimorphic effects on senescence characteristics of Drosophila melanogaster.多巴胺稳态的破坏对黑腹果蝇的衰老特征具有性别二态性影响。

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本文引用的文献

[InR gene expression and octopamine metabolism in Drosophila melanogaster females].[黑腹果蝇雌性体内的胰岛素受体底物基因表达与章鱼胺代谢]

Genetika. 2014 Mar;50(3):360-3.

Disruption of insulin signalling affects the neuroendocrine stress reaction in Drosophila females.胰岛素信号通路的破坏会影响果蝇雌性个体的神经内分泌应激反应。

J Exp Biol. 2014 Oct 15;217(Pt 20):3733-41. doi: 10.1242/jeb.106815. Epub 2014 Sep 11.

Insulin affects reproduction and juvenile hormone metabolism under normal and stressful conditions in Drosophila females.在正常和应激条件下，胰岛素会影响果蝇雌性的生殖和保幼激素代谢。

Dokl Biochem Biophys. 2013 Sep;452(1):264-6. doi: 10.1134/S1607672913050153. Epub 2013 Oct 23.

Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction.果蝇胰岛素样肽在代谢、衰老和饮食限制中的功能影响。

Front Physiol. 2013 Oct 16;4:288. doi: 10.3389/fphys.2013.00288.

Altered juvenile hormone metabolism, reproduction and stress response in Drosophila adults with genetic ablation of the corpus allatum cells.具有咽侧体细胞遗传消融的果蝇成虫中，保幼激素代谢、生殖和应激反应的改变。

Insect Biochem Mol Biol. 2010 Dec;40(12):891-7. doi: 10.1016/j.ibmb.2010.09.001. Epub 2010 Sep 16.

Dopamine down-regulates activity of alkaline phosphatase in Drosophila: the role of D2-like receptors.多巴胺下调果蝇碱性磷酸酶的活性：D2 样受体的作用。

J Insect Physiol. 2010 Sep;56(9):1155-9. doi: 10.1016/j.jinsphys.2010.03.014. Epub 2010 Mar 28.

Endocrine regulation of aging and reproduction in Drosophila.果蝇衰老与生殖的内分泌调节

Mol Cell Endocrinol. 2009 Feb 5;299(1):39-50. doi: 10.1016/j.mce.2008.07.005. Epub 2008 Jul 17.

Interplay of JH, 20E and biogenic amines under normal and stress conditions and its effect on reproduction.正常和应激条件下保幼激素、20-羟基蜕皮酮及生物胺的相互作用及其对生殖的影响

J Insect Physiol. 2008 Jun;54(6):902-8. doi: 10.1016/j.jinsphys.2008.04.004. Epub 2008 Apr 11.

Locomotor activity is regulated by D2-like receptors in Drosophila: an anatomic and functional analysis.果蝇的运动活性受D2样受体调控：解剖学与功能分析

Dev Neurobiol. 2007 Feb 15;67(3):378-93. doi: 10.1002/dneu.20355.

PLoS One. 2007 Jan 31;2(1):e187. doi: 10.1371/journal.pone.0000187.

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Interplay of insulin and dopamine signaling pathways in the control of Drosophila melanogaster fitness.

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