Clinical Psychology, University of Graz, BioTechMedGraz, Universitätsplatz 3, A-8010 Graz, Austria.
Clinical Psychology, University of Graz, BioTechMedGraz, Universitätsplatz 3, A-8010 Graz, Austria.
Psychiatry Res. 2015 Jun 30;232(3):203-7. doi: 10.1016/j.pscychresns.2015.04.002. Epub 2015 Apr 17.
The majority of morphometric studies on borderline personality disorder (BPD) found that diagnosed patients have a reduced amygdala volume. We sought to extend this finding by focusing on amygdala subdivisions (centromedial, laterobasal, superficial) and their association with symptom severity and disgust-related traits. Additional disorder-/disgust-relevant regions (insula, somatosensory cortex) were also investigated. We compared structural imaging data from 25 female BPD patients and 25 healthy women via voxel-based morphometry. Scores on self-report measures for symptom severity, disgust proneness, and self-disgust were correlated with gray matter volume (GMV) of regions of interest. Relative to controls, BPD patients had more GMV in the laterobasal amygdala. The volume of this region was positively correlated with symptom severity. In contrast, GMV of the centromedial amygdala showed a negative correlation with symptom severity. The degree of reported self-injury and self-disgust correlated negatively with the volume of the secondary somatosensory cortex (SII). Our data point to a differential contribution of amygdala subdivisions to symptom severity in BPD. Future longitudinal studies should focus on these subregions and possible volume changes during the course of the disorder. The meaning of altered SII volume for dysfunctional auto-aggressive behavior needs further investigation.
大多数关于边缘型人格障碍（BPD）的形态计量学研究发现，诊断为 BPD 的患者的杏仁核体积减小。我们通过关注杏仁核的细分区域（中央核、基底外侧核、浅层）及其与症状严重程度和与厌恶相关的特征的关系，试图扩展这一发现。还研究了其他与障碍/厌恶相关的区域（岛叶、体感皮层）。我们通过基于体素的形态计量学比较了 25 名女性 BPD 患者和 25 名健康女性的结构成像数据。通过自我报告的严重程度、易恶心和自我厌恶的评分与感兴趣区域的灰质体积（GMV）进行相关性分析。与对照组相比，BPD 患者的基底外侧杏仁核 GMV 较多。该区域的体积与症状严重程度呈正相关。相比之下，杏仁核中央核的 GMV 与症状严重程度呈负相关。报告的自我伤害和自我厌恶的程度与次级体感皮层（SII）的体积呈负相关。我们的数据表明，杏仁核细分区域对 BPD 患者的症状严重程度有不同的影响。未来的纵向研究应关注这些亚区以及在疾病过程中的可能体积变化。改变的 SII 体积对功能失调的自动攻击行为的意义需要进一步研究。
