Liao Jinmin, Yan Hao, Liu Qi, Yan Jun, Zhang Lanlan, Jiang Sisi, Zhang Xiao, Dong Zheng, Yang Wen, Cai Liwei, Guo Huining, Wang Yan, Li Zimeng, Tian Lin, Zhang Dai, Wang Fei
Peking University Sixth Hospital/Institute of Mental Health, 51 Hua Yuan Bei Road, Hai Dian District, Beijing 100191, China; National Clinical Research Center for Mental Disorders and Key Laboratory for Mental Health, Ministry of Health (Peking University), 51 Hua Yuan Bei Road, Hai Dian District, Beijing 100191, China.
Peking University Sixth Hospital/Institute of Mental Health, 51 Hua Yuan Bei Road, Hai Dian District, Beijing 100191, China; National Clinical Research Center for Mental Disorders and Key Laboratory for Mental Health, Ministry of Health (Peking University), 51 Hua Yuan Bei Road, Hai Dian District, Beijing 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, 5 Yi He Yuan Road, Hai Dian District, Beijing 100871, China.
J Psychiatr Res. 2015 Jun;65:80-6. doi: 10.1016/j.jpsychires.2015.04.008. Epub 2015 Apr 18.
Psychopathy is associated with dysfunction in regions that compose the paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole (TP), parahippocampal gyrus (PHG) and cingulate cortex (CC). However, findings of structural alterations in these regions are inconsistent in schizophrenia, and correlations between paralimbic system measures and symptomatology and cognitive function have not been investigated.
93 patients with schizophrenia and 99 healthy controls received structural magnetic resonance imaging and clinical and cognitive assessment. We compared gray matter volume (GMV) between the two groups using voxel-based morphometry, and evaluated correlations between abnormal GMVs and clinical variables, symptomatology and cognitive function. The assessment of cognition included measures of processing speed, verbal fluency and memory.
Patients with schizophrenia demonstrated significant GMV decreases in the paralimbic system, including bilateral OFC, IC and TP (p < 0.05, FWE corrected). GMV decreases were also observed in bilateral superior temporal gyri (STG). The GMVs in bilateral OFC, left IC, left TP and bilateral STG were positively correlated with processing speed, and the GMVs in bilateral OFC were positively correlated with memory function in all participants. In our patient group, the GMV deficits were also associated with earlier age of onset, longer duration of illness, greater number of hospitalizations and more severe positive symptoms.
GMVs in the paralimbic system were significantly reduced in schizophrenia, and these abnormalities were correlated with clinical variables, symptomatology and cognitive function. These results suggest the paralimbic system plays an important role in the pathophysiology of schizophrenia.
精神病态与构成边缘旁系统的区域功能障碍有关，如眶额皮质（OFC）、岛叶皮质（IC）、颞极（TP）、海马旁回（PHG）和扣带回皮质（CC）。然而，这些区域结构改变在精神分裂症中的研究结果并不一致，且边缘旁系统测量与症状学及认知功能之间的相关性尚未得到研究。
93例精神分裂症患者和99名健康对照者接受了结构磁共振成像以及临床和认知评估。我们使用基于体素的形态测量法比较了两组之间的灰质体积（GMV），并评估了异常GMV与临床变量、症状学和认知功能之间的相关性。认知评估包括处理速度、语言流畅性和记忆测量。
精神分裂症患者在边缘旁系统中表现出显著的GMV减少，包括双侧OFC、IC和TP（p < 0.05，FWE校正）。双侧颞上回（STG）也观察到GMV减少。在所有参与者中，双侧OFC、左侧IC、左侧TP和双侧STG的GMV与处理速度呈正相关，双侧OFC的GMV与记忆功能呈正相关。在我们的患者组中，GMV缺陷还与发病年龄较早、病程较长、住院次数较多和阳性症状较严重有关。
精神分裂症患者边缘旁系统的GMV显著降低，这些异常与临床变量、症状学和认知功能相关。这些结果表明边缘旁系统在精神分裂症的病理生理学中起重要作用。
