Dumke Charles L, Slivka Dustin R, Cuddy John S, Hailes Walter S, Rose Shawn M, Ruby Brent C
Department of Health and Human Performance, Montana Center for Work Physiology and Exercise Metabolism, University of Montana, Missoula, MT (Drs Dumke and Ruby, and Messrs. Cuddy, Hailes, and Rose).
School of Health, Physical Education and Recreation, University of Nebraska at Omaha, Omaha, NE (Dr Slivka).
Wilderness Environ Med. 2015 Sep;26(3):335-42. doi: 10.1016/j.wem.2015.03.002. Epub 2015 Apr 30.
The purpose of this study was to compare glucose and insulin responses during an oral glucose tolerance test (OGTT) in cold (C), neutral (N), and hot (H) environments.
Eleven males completed three 4-hour climate-controlled OGTT trials (C, 7.2°C; N, 22°C; and H, 43°C). Participants remained semireclined for 60 minutes before ingesting a 1.8 g/kg glucose beverage. Skin and rectal core temperatures were continuously monitored. Blood was collected just before glucose ingestion (time 0) and at 15, 30, 60, 90, 120, and 180 minutes, and analyzed for serum glucose, insulin, hematocrit, and hemoglobin. Expired gases were collected upon entering the chamber (-60 minutes), before glucose ingestion (0 minutes), and at 60, 120, and 180 minutes to determine V(O2) and respiratory exchange ratio.
Rectal core temperature was greater in the H condition compared with both C and N (P < .001). Rectal core temperature was not different between C and N, whereas skin temperature was different across all trials (H greater than N greater than C). The V(O2) was greater in C than in both H and N during all time points. Carbohydrate oxidation was greater in C compared with H and N (P < 0.001). Glucose was higher during H compared with C and N (P ≤ 0.002). Glucose was elevated in C compared with N. Insulin was higher in H compared with C (P = 0.009). Area under the curve for serum glucose was greater in H compared with C and N (P ≤ 0.001); however, there was no significant difference in area under the curve for insulin.
These data indicate that after an OGTT, glucose and insulin are elevated in a hot environment.
本研究旨在比较寒冷（C）、中性（N）和炎热（H）环境下口服葡萄糖耐量试验（OGTT）期间的血糖和胰岛素反应。
11名男性完成了三项为期4小时的气候控制OGTT试验（C，7.2°C；N，22°C；H，43°C）。参与者在摄入1.8 g/kg葡萄糖饮料前半躺60分钟。持续监测皮肤和直肠核心温度。在摄入葡萄糖前（0时刻）以及15、30、60、90、120和180分钟采集血液，分析血清葡萄糖、胰岛素、血细胞比容和血红蛋白。在进入试验舱时（-60分钟）、摄入葡萄糖前（0分钟）以及60、120和180分钟收集呼出气体，以测定耗氧量（V(O2)）和呼吸交换率。
与C和N条件相比，H条件下的直肠核心温度更高（P <.001）。C和N条件下的直肠核心温度无差异，而所有试验中的皮肤温度不同（H > N > C）。在所有时间点，C条件下的V(O2)均高于H和N。与H和N相比，C条件下的碳水化合物氧化更高（P < 0.001）。与C和N相比，H条件下的葡萄糖更高（P ≤ 0.002）。与N相比，C条件下的葡萄糖升高。与C相比，H条件下的胰岛素更高（P = 0.009）。H条件下血清葡萄糖曲线下面积大于C和N（P ≤ 0.001）；然而，胰岛素曲线下面积无显著差异。
这些数据表明，OGTT后，炎热环境下血糖和胰岛素升高。
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