Exercise Physiology Laboratory, Department of Kinesiology, Texas Christian University, Fort Worth, Texas, USA.
J Strength Cond Res. 2010 Apr;24(4):1091-101. doi: 10.1519/JSC.0b013e3181cc2212.
The purpose of this project was to examine the influence of resistance exercise (RE) intensities, resulting in different total volume loads on circulating interleukin-6 (IL-6), insulin and glucose response (IGR) to a carbohydrate feeding (CHO), and whether RE-induced IL-6 was associated with postexercise IGR. Fourteen men (21.7 +/- 1.7 years, 83 +/- 14.2 kg), performed 2 RE sessions (low-intensity resulting in high volume [65% 1-repetition maximum (1RM)], LO; high intensity resulting in low volume [85% 1RM], HI); and a nonexercise control trial (CON). Resistance exercise included 3 sets (LO = 12 reps, 12 reps, and failure; HI = 8 reps, 8 reps, and failure) of 8 exercises. Blood was obtained pre- (PR) and post (PO) exercise, and 6 hours postexercise (6H). Twenty-three hours after RE or CON, participants consumed 100 g dextrose (CHO) beverage. Blood was collected before (0 minutes) and 60 minutes after CHO (n = 6, phase 1) or every 30 minutes for a 2-hour oral glucose tolerance test (n = 8; phase 2). Circulating IL-6, insulin, and glucose were analyzed via enzyme-linked immunosorbent assay, radioimmunoassay, and enzymatic methods, respectively. Total volume load was higher in LO (17,729 +/- 1,466 kg) compared with HI (13,160 +/- 1,097 kg; p < 0.001). Postexercise IL-6 was elevated (p = 0.003) in LO and HI compared with CON (7.4 +/- 1.3, 5.2 +/- 0.7, and 2.5 +/- 0.7 pg.mL, respectively), with LO IL-6 greater than HI. Areas under the curve for glucose (p = 0.081; CON: 741 +/- 46, LO: 690 +/- 28, and HI: 660 +/- 21 mM.min) and insulin (p = 0.075; CON: 6,818 +/- 1,018, LO: 5,056 +/- 869, and HI: 5,405 +/- 1,076 microIU.mL) were not different among trials (n = 8). When 0- and 60-minute values were compared (n = 14), insulin was lower at 60 minutes in LO and HI compared with CON (55 + 9.1, 83 +/- 13, 105 +/- 13 microIU.mL, respectively) with LO insulin being lower than HI (p < 0.001). No relationship was observed between PO IL-6 and IGR, but PR IL-6 was negatively related to both PR (r = -0.043, p < 0.05) and 60 minutes (r = -0.59, p < 0.01) glucose (n = 14). These results indicate that TVL contributes to RE-induced IL-6 release and that TVL may be more important than RE intensity when improvements in glucose tolerance or IS are the goal.
本研究旨在探讨不同总运动量负荷（导致不同循环白细胞介素-6（IL-6）、胰岛素和葡萄糖反应（IGR））对碳水化合物摄入（CHO）的影响，以及运动引起的 IL-6 是否与运动后 IGR 有关。14 名男性（21.7±1.7 岁，83±14.2kg）进行了 2 次阻力运动（低强度导致高容量[65%1 重复最大值（1RM）]，LO；高强度导致低容量[85%1RM]，HI）；和非运动对照试验（CON）。阻力运动包括 8 种运动的 3 组（LO=12 次，12 次，失败；HI=8 次，8 次，失败）。运动前后（PR 和 PO）及运动后 6 小时（6H）采集血液。运动或 CON 后 23 小时，参与者摄入 100g 葡萄糖（CHO）饮料。在 0 分钟（0 分钟）和 60 分钟（n=6，第 1 阶段）或 2 小时口服葡萄糖耐量试验的每 30 分钟（n=8；第 2 阶段）后采集血液。通过酶联免疫吸附试验、放射免疫分析和酶法分别分析循环白细胞介素-6、胰岛素和葡萄糖。LO 的总运动量负荷（17729±1466kg）高于 HI（13160±1097kg；p<0.001）。与 CON 相比，LO 和 HI 运动后 IL-6 升高（p=0.003）（分别为 7.4±1.3、5.2±0.7 和 2.5±0.7pg.mL），LO IL-6 高于 HI。葡萄糖（p=0.081；CON：741±46、LO：690±28 和 HI：660±21mM.min）和胰岛素（p=0.075；CON：6818±1018、LO：5056±869 和 HI：5405±1076microIU.mL）的曲线下面积在试验之间没有差异（n=8）。当比较 0 分钟和 60 分钟的值（n=14）时，LO 和 HI 在 60 分钟时的胰岛素低于 CON（55+9.1、83±13 和 105±13microIU.mL），LO 胰岛素低于 HI（p<0.001）。PO IL-6 与 IGR 之间没有关系，但 PR IL-6 与 PR（r=-0.043，p<0.05）和 60 分钟（r=-0.59，p<0.01）葡萄糖呈负相关（n=14）。这些结果表明，TVL 有助于 RE 诱导的 IL-6 释放，当改善葡萄糖耐量或 IS 是目标时，TVL 可能比 RE 强度更重要。
