培养的人角质形成细胞中人类1,25 - 二羟基维生素D3受体和c - myc原癌基因的mRNA表达。
The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes.
作者信息
Hanafin N M, Persons K S, Holick M F
机构信息
Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston City Hospital, 80 East Concord Street, M-1013, Boston, Massachusetts 02118, USA.
出版信息
In Vitro Cell Dev Biol Anim. 1994 Mar;30A(3):187-91. doi: 10.1007/BF02631442.
PMID:25939167
Abstract
The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and confluent cultured human keratinocytes.
摘要
用10(-8)M 1,25(OH)2D3处理人培养的角质形成细胞24小时后，未汇合的人培养角质形成细胞中的人维生素D受体mRNA表达上调。此外，在未汇合和汇合的人培养角质形成细胞中，1,25(OH)2D3均以剂量依赖性方式降低人c-myc mRNA表达。
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