脂蛋白分离术
Lipoprotein apheresis.
作者信息
Moriarty Patrick M, Hemphill Linda
机构信息
Division of Clinical Pharmacology and Atherosclerosis/Lipoprotein-Apheresis Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 3008, Kansas City, KS 66160, USA.
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cardiol Clin. 2015 May;33(2):197-208. doi: 10.1016/j.ccl.2015.02.002.
Patients with familial hypercholesterolemia (FH) have early development of atherosclerosis and cardiovascular disease (CVD). Lipid level-lowering medications are not always successful in reducing increased low-density lipoprotein C (LDL-C) levels. Lipoprotein apheresis (LA) therapy has proven its clinical benefit in reducing CVD events for patients with FH with hypercholesterolemia. LA reduces LDL-C levels by more than 60% in patients with FH and reduces CVD events. LA also reduces Lp(a) levels and CVD events. LA reduces inflammatory markers and blood viscosity.
家族性高胆固醇血症（FH）患者早期会出现动脉粥样硬化和心血管疾病（CVD）。降脂药物在降低升高的低密度脂蛋白C（LDL-C）水平方面并不总是成功的。脂蛋白分离（LA）疗法已证明其对患有高胆固醇血症的FH患者在减少CVD事件方面具有临床益处。LA可使FH患者的LDL-C水平降低60%以上，并减少CVD事件。LA还可降低脂蛋白（a）水平和CVD事件。LA可降低炎症标志物和血液粘度。
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