可靠的定量 SERS 分析由具有嵌入式内标核壳纳米粒子提供支持。
Reliable Quantitative SERS Analysis Facilitated by Core-Shell Nanoparticles with Embedded Internal Standards.
机构信息
State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), MOE laboratory of Spectrochemical Analysis and Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China) http://bren.xmu.edu.cn.
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022 (China).
出版信息
Angew Chem Int Ed Engl. 2015 Jun 15;54(25):7308-12. doi: 10.1002/anie.201502171. Epub 2015 May 4.
Quantitative analysis is a great challenge in surface-enhanced Raman scattering (SERS). Core-molecule-shell nanoparticles with two components in the molecular layer, a framework molecule to form the shell, and a probe molecule as a Raman internal standard, were rationally designed for quantitative SERS analysis. The signal of the embedded Raman probe provides effective feedback to correct the fluctuation of samples and measuring conditions. Meanwhile, target molecules with different affinities can be adsorbed onto the shell. The quantitative analysis of target molecules over a large concentration range has been demonstrated with a linear response of the relative SERS intensity versus the surface coverage, which has not been achieved by conventional SERS methods.
定量分析是表面增强拉曼散射（SERS）的一大挑战。为此，我们设计了一种具有双分子层的核-分子-壳型纳米粒子，其中分子层包括一个形成壳的骨架分子和一个作为拉曼内标探针的分子。嵌入的拉曼探针的信号为定量 SERS 分析提供了有效的反馈，以校正样品和测量条件的波动。同时，不同亲和力的目标分子可以被吸附到壳上。我们已经证明，通过相对 SERS 强度与表面覆盖率的线性响应，可以实现目标分子在大浓度范围内的定量分析，这是传统 SERS 方法无法实现的。
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