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基于表面增强拉曼光谱的挥发性有机化合物分析中的金属有机框架

Metal-Organic Frameworks in Surface Enhanced Raman Spectroscopy-Based Analysis of Volatile Organic Compounds.

作者信息

Allegretto Juan A, Dostalek Jakub

机构信息

Laboratory for Life Sciences and Technology (LiST), Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, Krems, 3500, Austria.

FZU-Institute of Physics, Czech Academy of Sciences, Na Slovance 2, Prague, 82021, Czech Republic.

出版信息

Adv Sci (Weinh). 2024 Aug;11(30):e2401437. doi: 10.1002/advs.202401437. Epub 2024 Jun 13.

DOI:10.1002/advs.202401437
PMID:38868917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11321619/
Abstract

Volatile Organic Compounds (VOC) are a major class of environmental pollutants hazardous to human health, but also highly relevant in other fields including early disease diagnostics and organoleptic perception of aliments. Therefore, accurate analysis of VOC is essential, and a need for new analytical methods is witnessed for rapid on-site detection without complex sample preparation. Surface-Enhanced Raman Spectroscopy (SERS) offers a rapidly developing versatile analytical platform for the portable detection of chemical species. Nonetheless, the need for efficient docking of target analytes at the metallic surface significantly narrows the applicability of SERS. This limitation can be circumvented by interfacing the sensor surface with Metal-Organic Frameworks (MOF). These materials featuring chemical and structural versatility can efficiently pre-concentrate low molecular weight species such as VOC through their ordered porous structure. This review presents recent trends in the development of MOF-based SERS substrates with a focus on elucidating respective design rules for maximizing analytical performance. An overview of the status of the detection of harmful VOC is discussed in the context of industrial and environmental monitoring. In addition, a survey of the analysis of VOC biomarkers for medical diagnosis and emerging applications in aroma and flavor profiling is included.

摘要

挥发性有机化合物（VOC）是一类主要的环境污染物，对人类健康有害，但在其他领域也具有高度相关性，包括早期疾病诊断和食品的感官感知。因此，准确分析VOC至关重要，并且人们见证了对无需复杂样品制备即可进行快速现场检测的新分析方法的需求。表面增强拉曼光谱（SERS）为化学物质的便携式检测提供了一个快速发展的通用分析平台。尽管如此，目标分析物在金属表面的有效对接需求显著限制了SERS的适用性。通过将传感器表面与金属有机框架（MOF）连接，可以规避这一限制。这些具有化学和结构多功能性的材料可以通过其有序的多孔结构有效地预浓缩低分子量物质，如VOC。本综述介绍了基于MOF的SERS底物开发的最新趋势，重点是阐明各自的设计规则以最大化分析性能。在工业和环境监测的背景下讨论了有害VOC检测的现状概述。此外，还包括对用于医学诊断的VOC生物标志物分析以及在香气和风味剖析中的新兴应用的调查。

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