Tung Nguyen-Thach, Huyen Vu-Thu, Chi Sang-Cheol
Department of Pharmaceutics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam.
College of Pharmacy, Gachon University, Hambakmoeiro 191, Yeonsu-gu, Incheon, 406-799, Korea.
Arch Pharm Res. 2015 Nov;38(11):1999-2007. doi: 10.1007/s12272-015-0608-5. Epub 2015 May 5.
The potential of hydrogel containing nanostructured lipid carriers (NLC) to enhance the skin permeation rate and skin deposition of dexamethasone acetate (DEA) was investigated. The particle size of obtained NLCs was around 224.4 nm. NLCs had core-shell structure and DEA existed in amorphous state in NLCs. The permeation rate of DEA through excised mouse skins from hydrogel containing DEA-NLC (DEA-NLC-hydrogel) was 7.3 times higher than DEA-ointment. The skin deposition of DEA from DEA-NLC-hydrogel increased 3.8 folds compared to that from solution of DEA in hydrogel (DEA-hydrogel).
研究了含有纳米结构脂质载体（NLC）的水凝胶增强醋酸地塞米松（DEA）皮肤渗透速率和皮肤沉积的潜力。所制备的NLC粒径约为224.4nm。NLC具有核壳结构，且DEA在NLC中以无定形状态存在。DEA从含DEA-NLC的水凝胶（DEA-NLC-水凝胶）透过离体小鼠皮肤的渗透速率比DEA软膏高7.3倍。与DEA在水凝胶中的溶液（DEA-水凝胶）相比，DEA从DEA-NLC-水凝胶中的皮肤沉积增加了3.8倍。
