Jin Xiao-Ting, Zheng Kang, Li Yan-Tuan, Wu Zhi-Yong, Yan Cui-Wei
School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.
Key Laboratory of Marine Drug, Chinese Ministry of Education, Ocean University of China, Qingdao, 266003, People's Republic of China.
J Biochem Mol Toxicol. 2015 Aug;29(8):360-72. doi: 10.1002/jbt.21703. Epub 2015 May 4.
A new one-dimensional (1D) copper(II) coordination polymer {Cu2 (dmaepox)(dabt) · 0.5 H2 O}n , where H3 dmaepox and dabt denote N-benzoato-N'-(3-methylaminopropyl)oxamide and 2,2'-diamino-4,4'-bithiazole, respectively, was synthesized and characterized by single-crystal X-ray diffraction and other methods. The crystal structure analysis revealed that the two copper(II) ions are bridged alternately by cis-oxamido and carboxylato groups to form a 1-D coordination polymer with the corresponding Cu · · · Cu separations of 5.1946(19) and 5.038(2) Å. There is a three-dimensional supramolecular structure constructed by hydrogen bonding and π-π stacking interactions in the crystal. The reactivity towards herring sperm DNA (HS-DNA) and bovine serum albumin (BSA) indicated that the copper(II) polymer can interact with the DNA in the mode of intercalation, and bind to BSA responsible for quenching of tryptophan fluorescence by the static quenching mechanism. The in vitro cytotoxicity suggested that the copper(II) polymer exhibits cytotoxic effects against the selected tumor cell lines.
一种新型的一维（1D）铜（II）配位聚合物{Cu2 (dmaepox)(dabt) · 0.5 H2 O}n 被合成出来，其中H3 dmaepox和dabt分别表示N-苯甲酰基-N'-(3-甲基氨基丙基)草酰胺和2,2'-二氨基-4,4'-联噻唑，并通过单晶X射线衍射和其他方法对其进行了表征。晶体结构分析表明，两个铜（II）离子通过顺式草酰胺基和羧基交替桥连，形成一种一维配位聚合物，其相应的Cu···Cu间距为5.1946(19) Å和5.038(2) Å。晶体中通过氢键和π-π堆积相互作用构建了三维超分子结构。对鲱鱼精DNA（HS-DNA）和牛血清白蛋白（BSA）的反应性表明，铜（II）聚合物能以插入模式与DNA相互作用，并通过静态猝灭机制与BSA结合导致色氨酸荧光猝灭。体外细胞毒性表明，铜（II）聚合物对所选肿瘤细胞系具有细胞毒性作用。
