高半胱氨酸血症作为动脉粥样硬化的一个危险因素：综述。
Homocysteinemia as a risk factor for atherosclerosis: a review.
机构信息
Department of Surgery, Division of Vascular Surgery, Oregon Health Sciences University, Portland, Oregon USA.
出版信息
Cardiovasc Pathol. 1997 Jan;6(1):1-9. doi: 10.1016/S1054-8807(96)00064-6.
Elevation in plasma homocysteine has been widely studied as an independent risk factor for atherosclerosis. Animal laboratory models have demonstrated rapid onset vascular lesions with homocysteine infusion. A large body of data indicates a consistent relationship between plasma homocysteine and symptomatic atherosclerotic disease involving the coronary, peripheral, and cerebral circulations. Elevated plasma homocysteine can be predictably normalized with oral folate in most patients. Despite the wealth of published clinical data on this topic, it is unknown if normalization of plasma homocysteine in patients with symptomatic atherosclerosis will prevent or arrest the disease process.
血浆同型半胱氨酸水平升高已被广泛研究为动脉粥样硬化的独立危险因素。动物实验模型表明，同型半胱氨酸输注可迅速引起血管病变。大量数据表明，血浆同型半胱氨酸与涉及冠状动脉、外周和脑循环的有症状动脉粥样硬化疾病之间存在一致的关系。在大多数患者中，口服叶酸可使升高的血浆同型半胱氨酸水平得到可预测的正常化。尽管关于这个主题有大量已发表的临床数据，但尚不清楚在有症状的动脉粥样硬化患者中使血浆同型半胱氨酸正常化是否会预防或阻止疾病进程。
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