• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

复方丹参滴丸（通心络胶囊）对 2 型糖尿病患者心血管事件预防的血液黏度和血液流变学因素的有效性和安全性：系统评价和荟萃分析。

Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.

机构信息

College of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of Korea.

Department of Internal Medicine and Neuroscience, College of Korean Medicine, Wonkwang University, Iksandaero 460, Iksan 54538, Jeollabuk-do, Republic of Korea.

出版信息

Medicina (Kaunas). 2023 Sep 27;59(10):1730. doi: 10.3390/medicina59101730.

DOI:10.3390/medicina59101730
PMID:37893448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10608055/
Abstract

: Diabetes can cause various vascular complications. The Compounded Danshen-Dripping-Pill (CDDP) is widely used in China. This study aimed to analyze the effectiveness and safety of CDDP in the blood viscosity (BV) with type 2 diabetes mellitus (T2DM). : We conducted a systematic search of seven databases from their inception to July 2022 for randomized controlled trials that used CDDP to treat T2DM. To evaluate BV, we measured low shear rate (LSR), high shear rate (HSR), and plasma viscosity (PV). Homocysteine and adiponectin levels were also assessed as factors that could affect BV. : We included 18 studies and 1532 patients with T2DM. Meta-analysis revealed that CDDP significantly reduced LSR (mean difference [MD] -2.74, 95% confidence interval [CI] -3.77 to -1.72), HSR (MD -0.86, 95% CI -1.08 to -0.63), and PV (MD -0.37, 95% CI -0.54 to -0.19) compared to controls. CDDP also reduced homocysteine (MD -8.32, 95% CI -9.05 to -7.58), and increased plasma adiponectin (MD 2.72, 95% CI 2.13 to 3.32). Adverse events were reported less frequently in the treatment groups than in controls. : CDDP is effective in reducing BV on T2DM. However, due to the poor design and quality of the included studies, high-quality, well-designed studies are required in the future.

摘要

糖尿病可引起多种血管并发症。复方丹参滴丸（CDDP）在中国被广泛应用。本研究旨在分析 CDDP 对 2 型糖尿病（T2DM）患者血液黏度（BV）的有效性和安全性。

我们系统地检索了从建库到 2022 年 7 月 7 个数据库中的随机对照试验，这些试验使用 CDDP 治疗 T2DM。为了评估 BV，我们测量了低切变率（LSR）、高切变率（HSR）和血浆黏度（PV）。还评估了同型半胱氨酸和脂联素水平作为可能影响 BV 的因素。

我们纳入了 18 项研究，共 1532 例 T2DM 患者。Meta 分析显示，与对照组相比，CDDP 能显著降低 LSR（平均差 [MD] -2.74，95%置信区间 [CI] -3.77 至 -1.72）、HSR（MD -0.86，95% CI -1.08 至 -0.63）和 PV（MD -0.37，95% CI -0.54 至 -0.19）。CDDP 还能降低同型半胱氨酸（MD -8.32，95% CI -9.05 至 -7.58），增加血浆脂联素（MD 2.72，95% CI 2.13 至 3.32）。治疗组不良反应报告频率低于对照组。

CDDP 能有效降低 T2DM 患者的 BV。但是，由于纳入研究的设计和质量较差，未来需要进行高质量、精心设计的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/36b535513f0a/medicina-59-01730-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/d205331c4cef/medicina-59-01730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/29ec6847c930/medicina-59-01730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/75aed4aa7278/medicina-59-01730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/725e1e0b9b9c/medicina-59-01730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/c64a6b98cc1a/medicina-59-01730-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/f5f00271d83c/medicina-59-01730-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/90dee52b2359/medicina-59-01730-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/36b535513f0a/medicina-59-01730-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/d205331c4cef/medicina-59-01730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/29ec6847c930/medicina-59-01730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/75aed4aa7278/medicina-59-01730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/725e1e0b9b9c/medicina-59-01730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/c64a6b98cc1a/medicina-59-01730-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/f5f00271d83c/medicina-59-01730-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/90dee52b2359/medicina-59-01730-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4be/10608055/36b535513f0a/medicina-59-01730-g008.jpg

相似文献

1
Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.复方丹参滴丸（通心络胶囊）对 2 型糖尿病患者心血管事件预防的血液黏度和血液流变学因素的有效性和安全性：系统评价和荟萃分析。
Medicina (Kaunas). 2023 Sep 27;59(10):1730. doi: 10.3390/medicina59101730.
2
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病：网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
3
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状Meta分析。
Cochrane Database Syst Rev. 2020 Jan 9;1(1):CD011535. doi: 10.1002/14651858.CD011535.pub3.
4
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状荟萃分析。
Cochrane Database Syst Rev. 2017 Dec 22;12(12):CD011535. doi: 10.1002/14651858.CD011535.pub2.
5
Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis.抗血管内皮生长因子治疗糖尿病性黄斑水肿：一项网状Meta分析。
Cochrane Database Syst Rev. 2017 Jun 22;6(6):CD007419. doi: 10.1002/14651858.CD007419.pub5.
6
Dipeptidyl-peptidase (DPP)-4 inhibitors and glucagon-like peptide (GLP)-1 analogues for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk for the development of type 2 diabetes mellitus.二肽基肽酶（DPP）-4抑制剂和胰高血糖素样肽（GLP）-1类似物用于预防或延缓2型糖尿病高危人群发生2型糖尿病及其相关并发症。
Cochrane Database Syst Rev. 2017 May 10;5(5):CD012204. doi: 10.1002/14651858.CD012204.pub2.
7
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
8
Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus.饮食、体育活动或两者兼用，用于预防或延缓2型糖尿病高危人群发生2型糖尿病及其相关并发症。
Cochrane Database Syst Rev. 2017 Dec 4;12(12):CD003054. doi: 10.1002/14651858.CD003054.pub4.
9
Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis.抗血管内皮生长因子治疗糖尿病性黄斑水肿：一项网状Meta分析。
Cochrane Database Syst Rev. 2023 Jun 27;2023(6):CD007419. doi: 10.1002/14651858.CD007419.pub7.
10
Nutritional interventions for survivors of childhood cancer.儿童癌症幸存者的营养干预措施。
Cochrane Database Syst Rev. 2016 Aug 22;2016(8):CD009678. doi: 10.1002/14651858.CD009678.pub2.

引用本文的文献

1
Correlation Between Blood Coagulation Profile and Viscosity: Clinical Laboratory Observational Study.凝血指标与粘度之间的相关性：临床实验室观察性研究。
Med Sci (Basel). 2025 Feb 16;13(1):20. doi: 10.3390/medsci13010020.
2
Dilemmas in Elderly Diabetes and Clinical Practice Involving Traditional Chinese Medicine.老年糖尿病的困境与涉及中医药的临床实践
Pharmaceuticals (Basel). 2024 Jul 16;17(7):953. doi: 10.3390/ph17070953.
3
Diabetes, Hypertension and Cardiovascular Disease: Clinical Insights, Mechanisms and Pharmacotherapies.

本文引用的文献

1
Association between blood viscosity and early neurological deterioration in lacunar infarction.腔隙性脑梗死患者血液黏度与早期神经功能恶化的相关性
Front Neurol. 2022 Sep 20;13:979073. doi: 10.3389/fneur.2022.979073. eCollection 2022.
2
GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes.GATA3 作为免疫调节剂在肥胖相关代谢功能障碍中的作用，该障碍与脂肪肝疾病、胰岛素抵抗和 2 型糖尿病有关。
Chem Biol Interact. 2022 Oct 1;366:110141. doi: 10.1016/j.cbi.2022.110141. Epub 2022 Sep 2.
3
MD Simulation Studies for Selective Phytochemicals as Potential Inhibitors against Major Biological Targets of Diabetic Nephropathy.
糖尿病、高血压与心血管疾病：临床见解、机制与药物治疗
Medicina (Kaunas). 2024 Mar 30;60(4):566. doi: 10.3390/medicina60040566.
MD 模拟研究选择植物化学物质作为糖尿病肾病主要生物靶点的潜在抑制剂。
Molecules. 2022 Aug 5;27(15):4980. doi: 10.3390/molecules27154980.
4
Changes in the Blood Viscosity in Patients With SARS-CoV-2 Infection.新型冠状病毒肺炎患者的血液粘度变化
Front Med (Lausanne). 2022 Jun 17;9:876017. doi: 10.3389/fmed.2022.876017. eCollection 2022.
5
Blood Viscosity in Subjects With Type 2 Diabetes Mellitus: Roles of Hyperglycemia and Elevated Plasma Fibrinogen.2型糖尿病患者的血液粘度：高血糖和血浆纤维蛋白原升高的作用
Front Physiol. 2022 Feb 25;13:827428. doi: 10.3389/fphys.2022.827428. eCollection 2022.
6
Effect of diabetes blood-stasis syndrome and Xuefu Zhuyu decoction on ERK1/2-VEGF signal pathway in rat retina Müller cells.糖尿病血瘀证及血府逐瘀汤对大鼠视网膜Müller细胞ERK1/2-VEGF信号通路的影响
Histol Histopathol. 2022 Aug;37(8):757-767. doi: 10.14670/HH-18-427. Epub 2022 Feb 3.
7
Prevalence and Treatment of Diabetes in China, 2013-2018.中国糖尿病患病率及治疗状况 2013-2018 年
JAMA. 2021 Dec 28;326(24):2498-2506. doi: 10.1001/jama.2021.22208.
8
IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021.国际糖尿病联盟糖尿病地图集：2021 年全球成年人未诊断糖尿病估计数。
Diabetes Res Clin Pract. 2022 Jan;183:109118. doi: 10.1016/j.diabres.2021.109118. Epub 2021 Dec 6.
9
IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045.国际糖尿病联盟（IDF）糖尿病地图集：2021 年全球、区域和国家糖尿病患病率估算值以及 2045 年预测值。
Diabetes Res Clin Pract. 2022 Jan;183:109119. doi: 10.1016/j.diabres.2021.109119. Epub 2021 Dec 6.
10
Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses.复方丹参滴丸通过抑制氧化应激和炎症反应抑制高原缺氧损伤。
Pharm Biol. 2021 Dec;59(1):1585-1593. doi: 10.1080/13880209.2021.1998139.