Stevens An-Sofie, Pirotte Nicky, Wouters Annelies, Van Roten Andromeda, Van Belleghem Frank, Willems Maxime, Cuypers Ann, Artois Tom, Smeets Karen
Zoology: Biodiversity and Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590 Diepenbeek, Belgium.
Curr Drug Targets. 2016;17(12):1414-37. doi: 10.2174/1389450116666150506112817.
A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells.
致癌作用与组织再生过程之间存在微妙的平衡。许多恶性肿瘤被认为是再生过程受损或不完全的结果，导致细胞持续分裂。具有再生能力的组织和动物能够预防和对抗生长异常，并且似乎对化学致癌作用的易感性较低。癌细胞的存活除其他因素外，还取决于各种与氧化还原相关的机制，这些机制是目前开发的治疗方法的靶点。这些治疗方法的缺点是缺乏特异性和耐药性。由于这些与氧化还原相关的机制大多数在细胞的成功和协调运作及繁殖中也起着重要作用，因此再生过程为现代癌症研究提供了一个独特的平行背景。本综述重点关注再生与致癌作用之间的相互联系，以及对再生力和氧化还原控制机制的理解如何有助于识别新的治疗靶点，以阻止癌细胞的生长和存活。
