Yadav Rohan, Murthy Raghavendra Vasudeva, Kikkeri Raghavendra
Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune 411008 (India).
Chembiochem. 2015 Jul 6;16(10):1448-53. doi: 10.1002/cbic.201500162. Epub 2015 Jun 8.
Current methods for Alzheimer's treatment require a three-component system: metal chelators, antioxidants, and amyloid β (Aβ)-peptide-binding scaffolds. We report sialic acid (Sia) hydroxamate as a potential radical scavenger and metal chelator to inhibit Aβ aggregation. A cell viability assay revealed that Sia hydroxamate can protect HeLa and glioblastoma (LN229) cells from oxidative damage induced by the Fenton reaction. Sedimentation and turbidity assays showed profound protection of neuroblastoma SH-SY5Y cells from metal-induced Aβ aggregation and neural toxicity.
金属螯合剂、抗氧化剂和淀粉样β（Aβ）肽结合支架。我们报告了唾液酸（Sia）异羟肟酸作为一种潜在的自由基清除剂和金属螯合剂，可抑制Aβ聚集。细胞活力测定表明，Sia异羟肟酸可以保护HeLa细胞和胶质母细胞瘤（LN229）细胞免受芬顿反应诱导的氧化损伤。沉降和浊度测定表明，神经母细胞瘤SH-SY5Y细胞能得到有效保护，免受金属诱导的Aβ聚集和神经毒性的影响。
