Wadler S, Lyver A, Wiernik P H
Oncol Nurs Forum. 1989 Nov-Dec;16(6 Suppl):12-5.
Recombinant interferon (rIFN) modulates the cytotoxic effects of the fluorinated pyrimidine, 5-fluorouracil (5FU), in in vitro experimental tumor cell systems. In three clinical trials employing rIFN and 5FU in patients with advanced colorectal carcinoma conducted at the Albert Einstein College of Medicine, more than half the patients achieved an objective response. Of interest, the clinical spectrum of toxicities observed with this combination is different from those seen with either rIFN or 5FU alone. This novel constellation of toxicities includes a clinical syndrome characterized by watery diarrhea followed by life-threatening sepsis. Thus, careful observation and characterization of these toxicities are required. Patient education, with the goal of making patients recognize serious side effects, is important in the management of these patients.
重组干扰素（rIFN）在体外实验性肿瘤细胞系统中可调节氟化嘧啶5-氟尿嘧啶（5FU）的细胞毒性作用。在阿尔伯特·爱因斯坦医学院针对晚期结直肠癌患者开展的三项使用rIFN和5FU的临床试验中，超过半数的患者获得了客观缓解。有趣的是，该联合用药所观察到的毒性临床谱不同于单独使用rIFN或5FU时所见的毒性谱。这种新的毒性组合包括一种以水样腹泻随后发展为危及生命的脓毒症为特征的临床综合征。因此，需要对这些毒性进行仔细观察和特征描述。以让患者认识到严重副作用为目标的患者教育，在这些患者的管理中很重要。
