Institute of Biochemistry and Genetics of Ufa Scientific Centre RAS , Pr. Oktyabrya, Ufa , Russian Federation .
Clin Exp Hypertens. 2015;37(5):398-403. doi: 10.3109/10641963.2014.987394. Epub 2015 May 6.
Essential hypertension (EH) is a common disease with a clear genetic component. Inflammation and endothelial dysfunction play a prominent role in the development of persistent blood pressure elevation. The aim of the current study was to detect an association between EH and polymorphic markers in genes encoding for molecules involved in the control of intercellular interactions during the inflammation process. We analysed SNPs in SELE, SELP, SELL, ICAM1, VEGFA, IL1B, IL6, IL10 and IL12B genes in a group of 534 men of Tatar ethnicity (217 patients with EH and 317 controls). Using a Markov chain Monte-Carlo-based approach (APSampler), we found genotype and allelic combinations associated with EH. The most significant associations were observed for SELE rs2076059C-SELP rs6131A-VEGFA -2549I-IL1B rs16944C (p = 3.42 × 10(-5), FDR q = 0.035) and SELE rs2076059C-SELP rs6131A-IL12B rs3212227C-IL1B rs16944C (p = 323 × 10(-4), FDR q = 0.035).
原发性高血压（EH）是一种常见疾病，具有明确的遗传成分。炎症和内皮功能障碍在持续性血压升高的发展中起着重要作用。本研究的目的是检测参与炎症过程中细胞间相互作用控制的分子编码基因中的多态性标记与 EH 之间的关联。我们分析了塞莱（SELE）、SELp（SELP）、SELL（SELL）、细胞间黏附分子 1（ICAM1）、血管内皮生长因子 A（VEGFA）、白细胞介素 1B（IL1B）、白细胞介素 6（IL6）、白细胞介素 10（IL10）和白细胞介素 12B（IL12B）基因中的 SNP 在一组 534 名鞑靼族男性（217 名 EH 患者和 317 名对照）中。使用基于马尔可夫链蒙特卡罗的方法（APSampler），我们发现与 EH 相关的基因型和等位基因组合。观察到最显著的关联是 SELE rs2076059C-SELP rs6131A-VEGFA -2549I-IL1B rs16944C（p=3.42×10(-5)，FDR q=0.035）和 SELE rs2076059C-SELP rs6131A-IL12B rs3212227C-IL1B rs16944C（p=323×10(-4)，FDR q=0.035）。
