Meneses-Echávez Jose Francisco, González-Jiménez Emilio, Correa-Bautista Jorge Enrique, Valle Jacqueline Schmidt-Río, Ramírez-Vélez Robinson
Cad Saude Publica. 2015 Apr;31(4):667-81. doi: 10.1590/0102-311x00114414.
This study aimed to determine the effectiveness of physical exercise in decreasing fatigue in cancer patients during active treatment. The PubMed Central, EMBASE, and OVID databases were consulted up to April 2014 to identify randomized clinical trials that evaluated the effect of exercise on fatigue in cancer patients undergoing active treatment. Eleven studies (n = 1,407) were included. Chemotherapy was the most common form of treatment (n = 1,028). The studies showed a low risk of bias and high methodological quality. Effect estimates showed that physical exercise significantly improved fatigue (SMD = -3.0; 95%CI: -5.21; -0.80), p < 0.0001. Similar effects were found for resistance training (SMD = -4.5; 95%CI: -7.24; -1.82), p = 0.001. Significant improvements were found in breast and prostate cancer patients (p < 0.05). Exercise is a safe and effective intervention in the management fatigue in cancer patients undergoing active treatment.
本研究旨在确定体育锻炼对正在接受积极治疗的癌症患者减轻疲劳的有效性。截至2014年4月，检索了美国国立医学图书馆生物医学与健康科学图书馆、荷兰医学文摘数据库和OVID数据库，以识别评估锻炼对正在接受积极治疗的癌症患者疲劳影响的随机临床试验。纳入了11项研究（n = 1407）。化疗是最常见的治疗方式（n = 1028）。这些研究显示偏倚风险低且方法学质量高。效应估计表明，体育锻炼显著改善了疲劳（标准化均数差=-3.0；95%置信区间：-5.21；-0.80），p<0.0001。抗阻训练也有类似效果（标准化均数差=-4.5；95%置信区间：-7.24；-1.82），p = 0.001。乳腺癌和前列腺癌患者有显著改善（p<0.05）。锻炼是对正在接受积极治疗的癌症患者疲劳管理的一种安全有效的干预措施。
