Furlanut M, Montanari G, Benetello P, Bonin P, Schiaulini P, Pellegrino P A
Department of Pharmacology, University of Padua, Italy.
Pharmacol Res. 1989 Sep-Oct;21(5):561-6. doi: 10.1016/1043-6618(89)90197-7.
Thirty-seven children (6-13 years old), receiving a flexible dosage of imipramine (IMI) for nocturnal enuresis, were evaluated. After a mean time of 8.5 +/- 7.0 weeks of therapy, 40.5% no longer wet the bed; 32.4% had a mean benefit of 80%; 27.01% had a negligible response. The best relationship observed was between clinical effect and drug serum concentrations rather than with drug daily dose, the most satisfactory being that with IMI seric values (P = 0.019). Responders (effect higher than 50%) had higher IMI serum concentrations (P less than 0.05) than poor responders. At 3 and 6 months after stopping the drug, over 90% of the responders maintained the maximum response reached during treatment. The side-effects observed were irritability, reduction of appetite, headache, a mild increase of blood pressure.
对37名（6至13岁）接受灵活剂量丙咪嗪（IMI）治疗夜间遗尿症的儿童进行了评估。经过平均8.5±7.0周的治疗后，40.5%的儿童不再尿床；32.4%的儿童平均获益率为80%；27.01%的儿童反应可忽略不计。观察到的最佳关系是临床效果与药物血清浓度之间的关系，而非与药物日剂量的关系，最令人满意的是与IMI血清值的关系（P = 0.019）。反应者（效果高于50%）的IMI血清浓度高于反应不佳者（P < 0.05）。停药后3个月和6个月时，超过90%的反应者维持了治疗期间达到的最大反应。观察到的副作用有易怒、食欲减退、头痛、血压轻度升高。
