Preparation of a prolonged-release tablet formulation of diclofenac sodium. Part 1: Using chitosan.

Chitosan was used to prepare a prolonged-release tablet formulation of diclofenac sodium. Tablets were made by both direct-compression and wet granulation methods. The physical properties of tablets and granules were tested. The dissolution tests were performed by using USP dissolution and flow-through cell methods. A microcomputer program was used for the kinetic assessment of dissolution data. It was found that chitosan may be used for the preparation of the prolonged-release tablet of diclofenac sodium.