Alagiakrishnan Kannayiram
Division of Geriatric Medicine, Department of Medicine, University of Alberta, Edmonton, Canada,
Drugs Aging. 2015 May;32(5):337-48. doi: 10.1007/s40266-015-0263-z.
Hypotensive syndromes are common among older adults. Symptomatic drop in blood pressure with standing, eating and head turning is very common in older adults. These conditions cause significant morbidity like dizziness, syncope and falls as well as a resultant decrease in function. Blood pressure dysregulation due to autonomic function abnormalities plays a role in causing these conditions. Non-pharmacological measures should be the first line of management, but it is not always sufficient for subjects with symptomatic hypotensive syndromes. Different medication groups have been shown to be useful. This article focuses mainly on the medication management of these conditions based on efficacy and tolerability evidence in the literature. Standard medication management recommendations based on evidence are lacking for many medications used in treating these hypotensive syndromes.
低血压综合征在老年人中很常见。老年人在站立、进食和转头时出现有症状的血压下降非常普遍。这些情况会导致显著的发病率，如头晕、晕厥和跌倒，以及随之而来的功能下降。自主神经功能异常导致的血压调节失调在引发这些情况中起作用。非药物措施应作为一线治疗方法，但对于有症状的低血压综合征患者而言并不总是足够的。已证明不同的药物组是有用的。本文主要基于文献中的疗效和耐受性证据，重点讨论这些病症的药物治疗。治疗这些低血压综合征所使用的许多药物缺乏基于证据的标准药物治疗建议。
