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通过14年的追踪确定结核分枝杆菌菌株体内IS6110图谱的变化

In Vivo IS6110 Profile Changes in a Mycobacterium tuberculosis Strain as Determined by Tracking over 14 Years.

作者信息

Millán-Lou María Isabel, Otal Isabel, Monforte María Luisa, Vitoria María Asunción, Revillo María José, Martín Carlos, Samper Sofía

机构信息

Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain Hospital Universitario Miguel Servet, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain.

Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain Universidad de Zaragoza, Zaragoza, Spain.

出版信息

J Clin Microbiol. 2015 Jul;53(7):2359-61. doi: 10.1128/JCM.00607-15. Epub 2015 May 6.

DOI:10.1128/JCM.00607-15
PMID:25948604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4473185/
Abstract

Transposition and homologous recombination of IS6110 appear in Mycobacterium tuberculosis along in vivo sequential infections. These events were checked in different clones of a successful strain, M. tuberculosis Zaragoza, with the focus on a variant in which integration of a copy of IS6110 in the origin of replication (oriC) region occurred.

摘要

IS6110的转位和同源重组在结核分枝杆菌体内连续感染过程中出现。在一株成功的菌株——结核分枝杆菌萨拉戈萨株的不同克隆中检查了这些事件，重点关注一个在复制起点（oriC）区域发生IS6110拷贝整合的变体。

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BMC Microbiol. 2014 Feb 3;14:21. doi: 10.1186/1471-2180-14-21.
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Global study of IS6110 in a successful Mycobacterium tuberculosis strain: clues for deciphering its behavior and for its rapid detection.IS6110 在成功结核分枝杆菌菌株中的全球研究：揭示其行为并快速检测的线索。
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J Infect Dis. 2014 Jan 1;209(1):98-108. doi: 10.1093/infdis/jit439. Epub 2013 Aug 14.
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Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype.高拷贝数结核分枝杆菌菌株中 IS6110 的图谱显示，北京基因型有特定的插入点。
BMC Genomics. 2013 Jun 25;14:422. doi: 10.1186/1471-2164-14-422.
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Use of whole genome sequencing to determine the microevolution of Mycobacterium tuberculosis during an outbreak.应用全基因组测序技术分析结核分枝杆菌暴发期间的微进化。
PLoS One. 2013;8(3):e58235. doi: 10.1371/journal.pone.0058235. Epub 2013 Mar 5.
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BMC Genomics. 2012 Jun 15;13:249. doi: 10.1186/1471-2164-13-249.
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