Altamura C, Guercetti G, Percudani M
Institute of Clinical Psychiatry, University of Milan, Italy.
Psychiatry Res. 1989 Oct;30(1):69-75. doi: 10.1016/0165-1781(89)90173-x.
Fifty-four inpatients with a DSM-III diagnosis of schizophrenia were studied. Patients were divided into positive and negative subtypes of schizophrenia according to Andreasen's criteria. Blood samples were obtained from all patients for 2 consecutive days to determine plasma cortisol concentrations before and after a single administration (1 mg, p.o.) of dexamethasone at 11 p.m. The results revealed a significant increase in plasma cortisol levels in schizophrenic patients, with 40% of the patients being nonsuppressors on the dexamethasone suppression test. A higher percentage (62.5%) of patients with the negative form of schizophrenia were nonsuppressors.
对54名被诊断为精神分裂症（依据《精神疾病诊断与统计手册第三版》）的住院患者进行了研究。根据安德烈亚森的标准，将患者分为精神分裂症的阳性和阴性亚型。在连续两天从所有患者身上采集血样，以测定晚上11点单次口服（1毫克）地塞米松前后的血浆皮质醇浓度。结果显示，精神分裂症患者的血浆皮质醇水平显著升高，在进行地塞米松抑制试验时，40%的患者为非抑制者。阴性型精神分裂症患者的非抑制者比例更高（62.5%）。
