Patel Trupti S, Malvania Rujuta, Shah Majal C, Shah Manoj J, Gami Amisha G
Department of Pathology, MP Shah Cancer Hospital, Gujarat Cancer and Research Institute, Ahmadabad, Gujarat, India.
J Cytol. 2015 Jan-Mar;32(1):36-8. doi: 10.4103/0970-9371.155232.
Primary non-Hodgkin lymphoma of the liver is a very rare malignancy. In this case report, we describe a case of primary hepatic lymphoma (PHL) in a 60-year-old man who presented with lump and pain in the abdomen of 2 months' duration. The patient had altered liver function, normal serum alfa fetoprotein level (AFP), normal hemogram and bone marrow. A computed tomography scan of the abdomen and pelvis showed an ill-defined hypodense mass with specks of calcification involving the liver, suggestive of primary malignant mass of liver. Diagnosis of PHL was established on the cytology smear and confirmed by immunohistochemistry on tissue biopsy. This case demonstrates that PHL should be considered in the differential diagnosis of space-occupying liver lesions in the presence of a normal level of AFP. Fine needle aspiration cytology is a faster and safer diagnostic modality even in such a rare case. The case has many unique features like negative serology for viruses, no type B symptom and normal lactate dehydrogenase level.
原发性肝脏非霍奇金淋巴瘤是一种非常罕见的恶性肿瘤。在本病例报告中，我们描述了一例60岁男性的原发性肝淋巴瘤（PHL），该患者出现腹部肿块和疼痛2个月。患者肝功能异常，血清甲胎蛋白水平（AFP）正常，血常规和骨髓正常。腹部和骨盆的计算机断层扫描显示肝脏有一个边界不清的低密度肿块，伴有钙化斑点，提示肝脏原发性恶性肿块。通过细胞学涂片诊断为PHL，并经组织活检免疫组化证实。该病例表明，在AFP水平正常的情况下，鉴别肝脏占位性病变时应考虑PHL。即使在这种罕见病例中，细针穿刺细胞学检查也是一种更快、更安全的诊断方法。该病例有许多独特特征，如病毒血清学阴性、无B型症状和乳酸脱氢酶水平正常。
